重新思考炎症性肠病“应激”研究的方法学。
Reconsidering the methodology of "stress" research in inflammatory bowel disease.
机构信息
Department of Internal Medicine, Section of Gastroenterology and Nutrition, Rush University Medical Center, 1725 W. Harrison, Suite 206 Chicago, IL 60612, United States.
出版信息
J Crohns Colitis. 2008 Sep;2(3):193-201. doi: 10.1016/j.crohns.2008.01.002. Epub 2008 Mar 10.
Abstract
BACKGROUND AND AIMS
The goals of this paper are: 1) to critically review and analyze the methodology of the studies since 1990 linking stress to inflammatory bowel disease; and 2) to make recommendations for future research in this area of research.
METHODS
Articles were restricted to empirical reports in the English language with human subjects. Eleven empirical articles were able to answer "How is psychological stress related to inflammation and/or the expression or course of inflammatory bowel disease?"
RESULTS
Studies varied by choice of participant groups, method for classifying disease activity, choice of design, and definition and measurement of stress. Only half of the studies supported the hypothesis that stress affected IBD in some way.
CONCLUSIONS
Current methodological limitations in the stress and gut inflammation research have made it difficult for us to ascertain the role of stress in inflammatory bowel disease. Authors provide a checklist of items to consider when designing future studies.
摘要
背景与目的
本文的目标是：1）批判性地回顾和分析自 1990 年以来将压力与炎症性肠病联系起来的研究方法；2）为该领域的未来研究提出建议。
方法
本文仅限于以人类为对象的英语实证报告。有 11 篇实证文章能够回答“心理压力与炎症和/或炎症性肠病的表达或病程有何关系？”这一问题。
结果
研究因参与者群体的选择、疾病活动分类方法、设计选择以及压力的定义和测量而有所不同。只有一半的研究支持压力以某种方式影响 IBD 的假设。
结论
目前压力和肠道炎症研究中的方法学限制使得我们难以确定压力在炎症性肠病中的作用。作者提供了一份设计未来研究时需要考虑的项目清单。
相似文献
1
Reconsidering the methodology of "stress" research in inflammatory bowel disease.重新思考炎症性肠病“应激”研究的方法学。
J Crohns Colitis. 2008 Sep;2(3):193-201. doi: 10.1016/j.crohns.2008.01.002. Epub 2008 Mar 10.
2
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.在流行地区，服用抗叶酸抗疟药物的人群中，叶酸补充剂与疟疾易感性和严重程度的关系。
Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217.
3
A randomized controlled trial of a multicomponent online stress reduction intervention in inflammatory bowel disease.一项针对炎症性肠病的多成分在线减压干预的随机对照试验。
Therap Adv Gastroenterol. 2022 Sep 27;15:17562848221127238. doi: 10.1177/17562848221127238. eCollection 2022.
4
The role of psychological stress in inflammatory bowel disease: quality assessment of methods of 18 prospective studies and suggestions for future research.心理应激在炎症性肠病中的作用：18 项前瞻性研究方法的质量评估及对未来研究的建议。
Digestion. 2009;80(2):129-39. doi: 10.1159/000226087. Epub 2009 Aug 4.
5
The role of stress in the development and clinical course of inflammatory bowel disease: epidemiological evidence.应激在炎症性肠病发生发展及临床过程中的作用：流行病学证据
Curr Mol Med. 2008 Jun;8(4):247-52. doi: 10.2174/156652408784533832.
6
The Effectiveness of Integrated Care Pathways for Adults and Children in Health Care Settings: A Systematic Review.综合护理路径在医疗环境中对成人和儿童的有效性：一项系统评价。
JBI Libr Syst Rev. 2009;7(3):80-129. doi: 10.11124/01938924-200907030-00001.
7
The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients.儿童和成年患者中应激与炎症性肠病的相互作用
J Clin Med. 2024 Feb 27;13(5):1361. doi: 10.3390/jcm13051361.
8
The Impact of Inflammatory Bowel Disease in Canada 2018: Children and Adolescents with IBD.《2018年炎症性肠病在加拿大的影响：患有炎症性肠病的儿童和青少年》
J Can Assoc Gastroenterol. 2019 Feb;2(Suppl 1):S49-S67. doi: 10.1093/jcag/gwy056. Epub 2018 Nov 2.
9
Mediators of stress effects in inflammatory bowel disease: not the usual suspects.
J Psychosom Res. 2000 Jun;48(6):569-77. doi: 10.1016/s0022-3999(00)00098-2.
10
A Systematic Review of Sleep Disturbances in Pediatric Inflammatory Bowel Disease.小儿炎症性肠病睡眠障碍的系统评价
J Pediatr Psychol. 2023 Mar 20;48(3):267-282. doi: 10.1093/jpepsy/jsac088.
引用本文的文献
1
Mediating Role of Negative Affectivity in the Association Between Lifetime Trauma and Gastrointestinal Symptoms.消极情感性在终生创伤与胃肠道症状关联中的中介作用
Healthcare (Basel). 2025 Mar 28;13(7):755. doi: 10.3390/healthcare13070755.
2
Burden of Common Mental Disorders in Ulcerative Colitis and Irritable Bowel Syndrome Patients: An Analysis of Risk Factors.溃疡性结肠炎和肠易激综合征患者常见精神障碍的负担：危险因素分析
J Clin Med. 2025 Jan 14;14(2):499. doi: 10.3390/jcm14020499.
3
Correlation of mental and psychological status with disease activity in patients with inflammatory bowel disease using SCL-90 R Questionnaire.使用症状自评量表（SCL-90 R）问卷评估炎症性肠病患者心理和精神状态与疾病活动的相关性。
Prz Gastroenterol. 2024;19(2):165-174. doi: 10.5114/pg.2024.139579. Epub 2024 May 13.
4
The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients.儿童和成年患者中应激与炎症性肠病的相互作用
J Clin Med. 2024 Feb 27;13(5):1361. doi: 10.3390/jcm13051361.
5
Inflammatory Bowel Disease Disability Index is a valid and reliable measure of disability in an English-speaking hospital practice and predicts long-term requirement for treatment escalation.炎症性肠病残疾指数是一种在英语国家医院实践中对残疾情况进行有效且可靠评估的指标，并且能够预测长期治疗升级的需求。
Frontline Gastroenterol. 2023 Nov 10;15(2):130-136. doi: 10.1136/flgastro-2023-102428. eCollection 2024 Mar.
6
Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia's Gut Feeling.炎症性肠病的精神共病：这是一个关于小胶质细胞的直觉的问题。
Cells. 2024 Jan 17;13(2):177. doi: 10.3390/cells13020177.
7
Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease-An Overview.纳米和微粒中益生菌的递送策略：炎症性肠病治疗的趋势——综述
Pharmaceutics. 2023 Nov 8;15(11):2600. doi: 10.3390/pharmaceutics15112600.
8
Mental Illnesses in Inflammatory Bowel Diseases: .炎症性肠病中的精神疾病：综述。
Medicina (Kaunas). 2023 Mar 30;59(4):682. doi: 10.3390/medicina59040682.
9
Systematic review: the role of psychological stress in inflammatory bowel disease.系统评价：心理压力在炎症性肠病中的作用。
Aliment Pharmacol Ther. 2022 Oct;56(8):1235-1249. doi: 10.1111/apt.17202. Epub 2022 Sep 8.
10
The Influence of the Inflammatory Bowel Diseases on the Perceived Stress and Quality of Life in a Sample of the South-Western Romanian Population.炎症性肠病对罗马尼亚西南部人群样本中感知压力和生活质量的影响。
Curr Health Sci J. 2022 Jan-Mar;48(1):5-17. doi: 10.12865/CHSJ.48.01.01. Epub 2022 Mar 31.
本文引用的文献
1
Ulcerative Colitis: Studies of Personality.溃疡性结肠炎：人格研究。
Br Med J. 1938 Dec 31;2(4069):1356-60. doi: 10.1136/bmj.2.4069.1356.
2
Everyday stress and Crohn's disease activity: a time series analysis of 20 single cases.日常压力与克罗恩病活动：20例单病例的时间序列分析
Int J Behav Med. 1999;6(2):101-19. doi: 10.1207/s15327558ijbm0602_1.
3
Coping: pitfalls and promise.应对：陷阱与希望。
Annu Rev Psychol. 2004;55:745-74. doi: 10.1146/annurev.psych.55.090902.141456.
4
Relationships between perceived stress and health behaviors in a sample of working adults.在职成年人样本中感知压力与健康行为之间的关系。
Health Psychol. 2003 Nov;22(6):638-42. doi: 10.1037/0278-6133.22.6.638.
5
Psychosocial determinants of relapse in ulcerative colitis: a longitudinal study.溃疡性结肠炎复发的社会心理决定因素：一项纵向研究。
Am J Gastroenterol. 2003 Oct;98(10):2203-8. doi: 10.1111/j.1572-0241.2003.07717.x.
6
Stressful life events precede exacerbations of multiple sclerosis.压力大的生活事件先于多发性硬化症的病情加重。
Psychosom Med. 2002 Nov-Dec;64(6):916-20. doi: 10.1097/01.psy.0000038941.33335.40.
7
Review article: mechanisms of initiation and perpetuation of gut inflammation by stress.综述文章：应激引发和持续肠道炎症的机制
Aliment Pharmacol Ther. 2002 Dec;16(12):2017-28. doi: 10.1046/j.1365-2036.2002.01359.x.
8
Review on the influence of stress on immune mediators, neuropeptides and hormones with relevance for inflammatory bowel disease.应激对免疫介质、神经肽和激素的影响及其与炎症性肠病相关性的综述
Digestion. 2002;65(3):131-40. doi: 10.1159/000064933.
9
Psychological distress, social support, and disease activity in patients with inflammatory bowel disease.炎症性肠病患者的心理困扰、社会支持与疾病活动度
Am J Gastroenterol. 2001 May;96(5):1470-9. doi: 10.1111/j.1572-0241.2001.03800.x.
10
V. Stress and irritable bowel syndrome.五、压力与肠易激综合征
Am J Physiol Gastrointest Liver Physiol. 2001 Apr;280(4):G519-24. doi: 10.1152/ajpgi.2001.280.4.G519.
Zotero 插件