Nass Boukje Y S, Dibbets Pauline, Markus C Rob
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.
Dr. Rath Health Foundation, 6422 RG Heerlen, The Netherlands.
Healthcare (Basel). 2025 Mar 28;13(7):755. doi: 10.3390/healthcare13070755.
It is increasingly recognized that traumatic life experiences render individuals more vulnerable to gastrointestinal (GI) symptoms and chronic bowel conditions like inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). In this study, we examined whether this effect is mediated by negative affectivity. : A total of 281 participants recruited in the Netherlands, including 94 with IBD, 95 with IBS and 92 controls, were assessed for lifetime trauma, trait anxiety, depression, and GI (IBD/IBS) disease activity. : The results confirmed that negative affectivity fully mediated the association between trauma and GI symptomatology, with trauma and depression explaining 38-40% (IBD|IBS) of the variance in disease activity and trauma and anxiety explaining 31-33% (IBD|IBS) of the variance in disease activity. Upon correction for condition (patient/controls), the predictive capacity increased even further, with trauma and depression now accounting for 43-44% (IBD|IBS) and trauma and anxiety for 40% (IBD and IBS) of the GI symptom heterogeneity. : The results are in line with studies linking trauma to negative affectivity and negative affectivity to a more aggressive GI disease course. More generally, they show that the somatic and affective consequences of trauma should not be considered in isolation but must be treated as a covariant whole.
人们越来越认识到，创伤性的生活经历会使个体更容易出现胃肠道（GI）症状以及诸如炎症性肠病（IBD）和肠易激综合征（IBS）等慢性肠道疾病。在本研究中，我们检验了这种效应是否由消极情感介导。共有281名在荷兰招募的参与者接受了评估，其中包括94名IBD患者、95名IBS患者和92名对照者，评估内容包括终生创伤、特质焦虑、抑郁以及胃肠道（IBD/IBS）疾病活动情况。结果证实，消极情感完全介导了创伤与胃肠道症状之间的关联，创伤和抑郁解释了疾病活动差异的38 - 40%（IBD|IBS），创伤和焦虑解释了疾病活动差异的31 - 33%（IBD|IBS）。在对疾病状况（患者/对照者）进行校正后，预测能力进一步提高，创伤和抑郁现在占胃肠道症状异质性的43 - 44%（IBD|IBS），创伤和焦虑占40%（IBD和IBS）。这些结果与将创伤与消极情感以及消极情感与更具侵袭性的胃肠道疾病病程联系起来的研究一致。更普遍地说，它们表明创伤的躯体和情感后果不应被孤立地考虑，而必须作为一个协变整体来对待。
