Goëau-Brissonnière Olivier, Javerliat Isabelle, Koskas Fabien, Coggia Marc, Pechère Jean-Claude
Department of Vascular Surgery, Ambroise Paré University Hospital, Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt, France.
Ann Vasc Surg. 2011 Jan;25(1):134-42. doi: 10.1016/j.avsg.2010.09.002.
Postoperative wound and graft infections remain a major challenge for vascular surgeons. The bonding of antimicrobial substances on the graft material has been considered for many years, but the demonstration of safety and efficacy of these techniques is far from evident. Among the different proposed options, bonding of rifampin to the grafts has been the most evaluated technique, both experimentally and clinically. The objective of this review was to present and analyze the available data on rifampin-bonding and the possible evolutions of this technique to improve the resistance of vascular prostheses.
术后伤口和移植物感染仍然是血管外科医生面临的重大挑战。多年来，人们一直在考虑将抗菌物质结合到移植物材料上，但这些技术的安全性和有效性远未得到证实。在提出的不同选择中，利福平与移植物的结合是在实验和临床方面评估最多的技术。本综述的目的是介绍和分析关于利福平结合的现有数据以及该技术可能的改进方向，以提高血管假体的抗感染能力。
