Moran J S, Zenilman J M
Division of Sexually Transmitted Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
Rev Infect Dis. 1990 Jul-Aug;12 Suppl 6:S633-44. doi: 10.1093/clinids/12.supplement_6.s633.
The choice of therapy for Neisseria gonorrhoeae infections is complicated by antibiotic resistance and by the varying efficacy of some antibiotics at different anatomic sites of infection. Ceftriaxone (a single intramuscular dose of 250 mg) is a simple, effective, and generally well-tolerated choice for uncomplicated N. gonorrhoeae infection at all anatomic sites. Alternatives include single-dose oral regimens of ciprofloxacin, norfloxacin, and cefuroxime axetil as well as single-dose intramuscular regimens of spectinomycin, ceftizoxime, and cefotaxime. The addition of doxycycline (100 mg orally twice a day for 7 days) is recommended for presumptive treatment of chlamydial coinfection. Tetracyclines should not be used as sole therapy for gonococcal infection because of gonococcal resistance.
淋病奈瑟菌感染的治疗选择因抗生素耐药性以及某些抗生素在不同感染解剖部位疗效各异而变得复杂。头孢曲松（单次肌内注射250毫克）对于所有解剖部位的单纯性淋病奈瑟菌感染而言，是一种简便、有效且通常耐受性良好的选择。替代方案包括环丙沙星、诺氟沙星和头孢呋辛酯的单剂量口服疗法，以及大观霉素、头孢唑肟和头孢噻肟的单剂量肌内疗法。对于衣原体合并感染的推测性治疗，建议加用多西环素（口服100毫克，每日两次，共7天）。由于淋病奈瑟菌耐药，四环素不应作为淋病奈瑟菌感染的单一疗法使用。
