单剂量米诺环素治疗淋菌性尿道炎。与细菌耐药性相关的临床疗效及其对沙眼衣原体合并感染的影响。
Single-dose minocycline in the treatment of gonococcal urethritis. Clinical efficacy in relation to bacterial resistance and its effects on associated Chlamydia trachomatis infections.
作者信息
Waterworth P M, Oriel J D, Ridgway G L, Subramanian S
出版信息
Br J Vener Dis. 1979 Oct;55(5):343-7. doi: 10.1136/sti.55.5.343.
Seventy-two men with gonococcal urethritis were given a single 300-mg dose of minocycline. The failure rate was 13% and the trial was terminated at an early stage. Failure was correlated with increased resistance of Neisseria gonorrhoeae to minocycline. The activity of penicillin, spectinomycin, erythromycin, tetracycline, sulphamethoxazole, cefuroxime, cefotaxime, rosamicin, thiamphenicol, and piperacillin against N. gonorrhoeae were examined in vitro. With the exception of spectinomycin, parallel patterns of resistance to the other antibiotics and minocycline were found. Resistance to spectinomycin was not found, confirming the usefulness of this antibiotic in the treatment of gonorrhoea. The incidence of PGU was significantly lower after a single dose of minocycline than in previous studies.
72名患有淋菌性尿道炎的男性接受了单次300毫克剂量的米诺环素治疗。失败率为13%，该试验在早期阶段终止。治疗失败与淋病奈瑟菌对米诺环素耐药性增加有关。对青霉素、壮观霉素、红霉素、四环素、磺胺甲恶唑、头孢呋辛、头孢噻肟、罗沙米星、甲砜霉素和哌拉西林对淋病奈瑟菌的体外活性进行了检测。除壮观霉素外，发现对其他抗生素和米诺环素的耐药模式相似。未发现对壮观霉素耐药，证实了该抗生素在治疗淋病中的有效性。单次服用米诺环素后，持续性尿道炎（PGU）的发生率明显低于以往研究。
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