Jacobson J, Bergquist C, Rydnert J, Bokström H, Huovinen K
Department of Obstetrics and Gynecology of Södertälji Skukhus, Sweden.
Acta Obstet Gynecol Scand. 1990;69(2):135-8. doi: 10.3109/00016349009006158.
Milligram-range doses of E2 prostaglandins have long been used to induce labor or abortion in the second and third trimesters of pregnancy. Enprostil, a synthetic dehydroprostaglandin E2 structural analogue, is administered in microgram doses for the treatment of acute duodenal ulcer and acute gastric ulcer. This study examined the effect of the ulcer-healing dose and twice the ulcer-healing dose upon women in the first trimester of pregnancy. Two hundred and seven women who had requested legal abortion in the first trimester participated in two randomized, double-blind, placebo-controlled, parallel studies. They received two doses of enprostil 35 micrograms (the recommended dose for the treatment of duodenal and gastric ulcer) (n = 51), 70 micrograms (twice the recommended dose) (n = 53), or placebo (n = 103) 12 h apart. No drug-induced abortions occurred in any of the first-trimester pregnancies. Vaginal bleeding occurred in 4% of volunteers receiving the lower dose and 4% receiving the higher dose of enprostil. Vaginal bleeding occurred in up to 2% of volunteers on placebo. Although not recommended for pregnant women, if enprostil is given inadvertently to pregnant women with ulcers, it is unlikely to endanger the pregnancy during the first trimester.
毫克级剂量的E2前列腺素长期以来一直用于诱导妊娠中期和晚期的分娩或流产。恩前列素是一种合成的脱氢前列腺素E2结构类似物，以微克剂量给药用于治疗急性十二指肠溃疡和急性胃溃疡。本研究考察了溃疡愈合剂量和两倍溃疡愈合剂量对妊娠早期女性的影响。207名要求在妊娠早期进行合法堕胎的女性参与了两项随机、双盲、安慰剂对照的平行研究。她们接受两剂35微克恩前列素（十二指肠和胃溃疡治疗的推荐剂量）（n = 51）、70微克（推荐剂量的两倍）（n = 53）或安慰剂（n = 103），间隔12小时给药。在任何妊娠早期的妊娠中均未发生药物诱导的流产。接受较低剂量恩前列素的志愿者中有4%发生阴道出血，接受较高剂量恩前列素的志愿者中有4%发生阴道出血。接受安慰剂的志愿者中阴道出血发生率高达2%。尽管不推荐给孕妇，但如果不慎将恩前列素给予患有溃疡的孕妇，在妊娠早期不太可能危及妊娠。
