Tsunemine Hiroko, Akasaka Hiroshi, Kusama Toshiyuki, Fujimoto Koji, Motoyama Arata, Aozasa Katsuyuki, Kodaka Taiichi
Department of Hematology, Shinko Hospital, Kobe.
Intern Med. 2010;49(24):2703-7. doi: 10.2169/internalmedicine.49.3828. Epub 2010 Dec 15.
A 78-year-old woman with multiple tumors in the liver and spleen was diagnosed with follicular dendritic cell (FDC) sarcoma based on the histological picture of splenectomized specimen and its expression of CD21 and CD 23. As a paraneoplastic immune disorder, Coombs' test was positive although hemolysis was not obvious. Since systemic chemotherapies were ineffective for residual liver tumors, transcatheter arterial chemoembolization (TACE) was performed with subsequent tumor reduction. Currently, the patient is alive 27 months after the diagnosis with residual hepatic tumors favorably controlled by repeated TACE. Our experience suggests that TACE is useful for the management of hepatic FDC sarcoma.
一名78岁女性,肝脏和脾脏有多个肿瘤,根据脾切除标本的组织学图像及其CD21和CD23表达,被诊断为滤泡树突状细胞(FDC)肉瘤。作为一种副肿瘤性免疫紊乱,虽然溶血不明显,但库姆斯试验呈阳性。由于全身化疗对残留肝肿瘤无效,因此进行了经动脉化疗栓塞术(TACE),随后肿瘤缩小。目前,该患者在诊断后27个月仍然存活,残留肝肿瘤通过反复TACE得到良好控制。我们的经验表明,TACE对肝FDC肉瘤的治疗有用。