射频消融联合经导管治疗兔VX2肝癌：疗效及组织病理学特征
Radiofrequency ablation combined with transcatheter therapy in rabbit VX2 liver tumors: effects and histopathological characteristics.
作者信息
Duan XuHua, Zhou GuoFeng, Han XinWei, Ren JianZhuang, Zheng ChuanSheng, Liang HuiMin, Feng GanSheng
机构信息
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China Department of Interventional Radiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan Province, People's Republic of China.
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
出版信息
Acta Radiol. 2015 Jan;56(1):87-96. doi: 10.1177/0284185113520266. Epub 2014 Jan 14.
BACKGROUND
Transarterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) treatment (TACE-RFA) has been confirmed superior to TACE or RFA alone in animal liver tumors. TACE before RFA was shown to increase hepatocellular damage. Further optimization of the combination strategy for transcatheter arterial embolization (TAE) or TACE combined with RFA is warranted.
PURPOSE
To determine the optimal strategy for radiofrequency ablation combined with transcatheter therapies in VX2 liver tumors in a rabbit model.
MATERIAL AND METHODS
Twenty-four Japanese White rabbits with VX2 liver tumors were randomly divided into four groups: TACE-RFA (TACE-RFA group), transcatheter arterial embolization (TAE) combined with RFA treatment (TAE-RFA group), RFA only group, and TACE only group. Blood samples were collected 1 day before the operation and at 3 and 7 days postoperatively. Seven days after the operation, maximal diameters of coagulation or infarcted zones in the gross specimens, CT images, histopathological characteristics, tumor necrotic rate, and growth rate were compared.
RESULTS
Significantly larger mean long-axis (P < 0.05) and short-axis (P < 0.05) diameters of coagulation and infarction were observed in the TACE-RFA group compared with the TAE-RFA, RFA, and TACE groups on day 7; and the TAE-RFA group showed a significant (P < 0.05) increase versus the RFA and TACE groups on day 7. There were no significant differences in tumor growth rate (109.3 ± 37.5 vs. 119.0 ± 43.1%, P = 0.45) and necrotic rate (89.5 ± 12.0 vs. 83.5 ± 9.3%, P = 0.73) between the TACE-RFA and TAE-RFA groups. TACE-RFA was more effective for achieving tumor destruction than the other treatment strategies, but led to increased rabbits discomfort and more severe liver dysfunction compared with TAE-RFA.
CONCLUSION
TAE-RFA appears to be a beneficial therapeutic modality for treating VX2 liver tumors in a rabbit model.
背景
经动脉化疗栓塞术（TACE）联合射频消融术（RFA）治疗（TACE-RFA）在动物肝肿瘤模型中已被证实优于单纯TACE或RFA。RFA前进行TACE可增加肝细胞损伤。因此有必要进一步优化经导管动脉栓塞术（TAE）或TACE联合RFA的联合策略。
目的
确定兔VX2肝肿瘤模型中射频消融联合经导管治疗的最佳策略。
材料与方法
将24只患有VX2肝肿瘤的日本白兔随机分为四组：TACE-RFA组（TACE-RFA组）、经导管动脉栓塞术（TAE）联合RFA治疗组（TAE-RFA组）、单纯RFA组和单纯TACE组。在手术前1天、术后3天和7天采集血样。术后7天，比较大体标本、CT图像中凝固或梗死灶的最大直径、组织病理学特征、肿瘤坏死率和生长率。
结果
术后第7天，TACE-RFA组的凝固和梗死平均长径（P<0.05）和短径（P<0.05）明显大于TAE-RFA组、RFA组和TACE组；TAE-RFA组在术后第7天与RFA组和TACE组相比有显著增加（P<0.05）。TACE-RFA组与TAE-RFA组的肿瘤生长率（109.3±37.5对119.0±43.1%，P=0.45）和坏死率（89.5±12.0对83.5±9.3%，P=0.73）无显著差异。与其他治疗策略相比，TACE-RFA在实现肿瘤破坏方面更有效，但与TAE-RFA相比，会导致兔不适增加和更严重的肝功能障碍。
结论
TAE-RFA似乎是兔VX2肝肿瘤模型的一种有益治疗方式。
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