Department of Ophthalmology, International Islamic University Malaysia, Kuantan, Malaysia.
J Glaucoma. 2012 Jan;21(1):41-4. doi: 10.1097/IJG.0b013e3181fc8053.
To investigate the influence of myopia on peripapillary retinal nerve fiber layer (RNFL) thickness using Cirrus optical coherence tomography (OCT) in normal eyes.
Ninety-eight eyes of normal participants with various degrees of myopia were recruited in this study. The RNFL thickness was measured with high-definition (HD), spectral-domain Cirrus OCT (Cirrus HD-OCT; Carl Zeiss, Dublin, CA). The association between RNFL thickness and its spherical equivalent was evaluated with linear regression analysis.
The RNFL thickness was 119.2±16.8 μm, 117.1±16.8 μm, 75.9±16.1 μm, and 64.9±9.8 μm in the superior, inferior, temporal, and nasal quadrants, respectively, with an average thickness of 94.3±8.6 μm. The mean RNFL thickness was thinner in highly and moderately myopic eyes (93±7.9 μm and 92.6±7.7 μm, respectively, P=0.0001) compared with low myopic eyes (102.2±9 μm). A significant linear correlation was found between the spherical equivalent and the RNFL thickness in the superior (r=0.386, P=0.0001) and inferior quadrants (r=0.448, P=0.0001), and the average RNFL thickness (r=0.373, P=0.0001).
Myopia can be a confounding factor in the assessment of RNFL thickness attributed to its influence on the RNFL thickness. Therefore, we recommend a careful interpretation of RNFL data, especially those obtained from eyes with moderate-to-high myopia.
使用 Cirrus 光学相干断层扫描（OCT）研究正视眼中近视对周边视网膜神经纤维层（RNFL）厚度的影响。
本研究纳入了 98 例不同程度近视的正常受试者的双眼。使用高清（HD）、频域 Cirrus OCT（Cirrus HD-OCT；Carl Zeiss，Dublin，CA）测量 RNFL 厚度。采用线性回归分析评估 RNFL 厚度与其等效球镜之间的关系。
上、下、颞、鼻象限的 RNFL 厚度分别为 119.2±16.8μm、117.1±16.8μm、75.9±16.1μm 和 64.9±9.8μm，平均厚度为 94.3±8.6μm。高度近视和中度近视眼（93±7.9μm 和 92.6±7.7μm，P=0.0001）的平均 RNFL 厚度明显较低度近视眼（102.2±9μm）薄。等效球镜与上象限（r=0.386，P=0.0001）和下象限（r=0.448，P=0.0001）以及平均 RNFL 厚度（r=0.373，P=0.0001）均呈显著正相关。
近视可能是影响 RNFL 厚度评估的混杂因素，因此，我们建议对 RNFL 数据，尤其是中高度近视眼获得的 RNFL 数据进行仔细解读。
