Sonka Karel, Kemlink David, Busková Jitka, Pretl Martin, Srůtková Zuzana, Maurovich Horvat Eszter, Vodicka Pavel, Poláková Veronika, Nevsímalová Sona
Department of Neurology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
Neuro Endocrinol Lett. 2010;31(5):631-4.
Narcolepsy with cataplexy (NC) differs from narcolepsy without cataplexy (NwoC) in the cerebrospinal fluid levels of hypocretin. Since hypocretin is known to regulate not only wakefulness but also eating behaviour, we decided to compare the two entities for body mass index (BMI) and the presence of obesity.
Clinical data on patients with NC and NwoC was studied and examined, including nocturnal polysomnography and the Multiple Sleep Latency Test (MSLT). The results were rated against a group of age- and sex-matched healthy controls.
The BMI in NC (29.1±SD=5.8) was significantly higher than in NwoC (25.4±4.4) or in the controls (25.8±3.9) (p<0.001, F=17.4, df= 323), while no difference in BMI was found between NwoC and the controls. The proportion of patients with BMI >30 was significantly greater in NC (39.0%) than in NwoC (13.8%) or than in the control group (13.0%). A negative correlation of BMI and sleep latency in MSLT (p=0.009) was found in the combined NC and NwoC groups.
Unlike NC, NwoC has neither a higher BMI nor a higher incidence of obesity than the general population.
伴猝倒发作的发作性睡病（NC）与不伴猝倒发作的发作性睡病（NwoC）在脑脊液中下丘脑分泌素水平上存在差异。由于已知下丘脑分泌素不仅调节清醒状态，还调节进食行为，我们决定比较这两种疾病在体重指数（BMI）和肥胖症方面的情况。
研究并检查了NC和NwoC患者的临床数据，包括夜间多导睡眠图和多次睡眠潜伏期试验（MSLT）。将结果与一组年龄和性别匹配的健康对照进行比较。
NC患者的BMI（29.1±标准差=5.8）显著高于NwoC患者（25.4±4.4）或对照组（25.8±3.9）（p<0.001，F=17.4，自由度=323），而NwoC患者与对照组之间的BMI没有差异。BMI>30的患者比例在NC组（39.0%）显著高于NwoC组（13.8%）或对照组（13.0%）。在NC和NwoC合并组中发现BMI与MSLT中的睡眠潜伏期呈负相关（p=0.009）。
与NC不同，NwoC的BMI和肥胖症发病率均不比普通人群高。
