Nat Cell Biol. 2011 Jan;13(1):8-9. doi: 10.1038/ncb0111-8.
Despite their potential importance as therapeutic targets, the initial events in neurodegenerative diseases are poorly understood. Emerging evidence suggests that presynaptic dysfunction might be an early event in these pathologies, and three papers now link dysregulation of SNAREprotein levels and function caused by the absence of synuclein or cysteine string protein (CSP) to activity-dependent neurodegeneration.
尽管它们作为治疗靶点具有潜在的重要性，但神经退行性疾病的初始事件仍知之甚少。新出现的证据表明，突触前功能障碍可能是这些病变的早期事件，现在有三篇论文将由于缺乏突触核蛋白或半胱氨酸 string 蛋白 (CSP) 导致 SNARE 蛋白水平和功能的失调与活性依赖性神经退行性变联系起来。
