Moser Anna, Hsu Hsiang-Ting, van Endert Peter
F1000 Biol Rep. 2010 Oct 21;2:75. doi: 10.3410/B2-75.
Recognition of pancreatic beta cell antigens by autoreactive T lymphocytes plays a central role in the pathogenesis of insulin-dependent type 1 diabetes. Recent results suggest that non-conventional antigenic epitope processing and presentation may contribute to triggering and maintaining autoreactive responses. Moreover, promising results raise hope that autoantigens may become safe and specific therapeutics for type 1 diabetes in the future.
自身反应性T淋巴细胞对胰腺β细胞抗原的识别在胰岛素依赖型1型糖尿病的发病机制中起核心作用。最近的研究结果表明，非常规的抗原表位加工和呈递可能有助于引发和维持自身反应性应答。此外，有前景的研究结果让人们燃起希望，即自身抗原未来可能成为治疗1型糖尿病安全且特效的疗法。
