Hardwick Kevin G, Shah Jagesh V
F1000 Biol Rep. 2010 Jul 22;2:55. doi: 10.3410/B2-55.
The spindle checkpoint delays anaphase onset in the presence of defective kinetochore-microtubule attachments. Such delays can last for just a few minutes or several hours, but very shortly after all chromosomes achieve bi-orientation, a remarkably synchronous anaphase ensues. We are beginning to understand the pathways involved in silencing spindle checkpoint signals and subsequent activation of the anaphase-promoting complex. Here, we review recent advances made in our understanding of the molecular mechanisms regulating this critical cell cycle transition.
纺锤体检查点在动粒-微管连接存在缺陷时会延迟后期开始。这种延迟可能只持续几分钟或几个小时，但在所有染色体实现双定向后不久，就会紧接着出现非常同步的后期。我们开始了解参与消除纺锤体检查点信号以及随后激活后期促进复合物的途径。在这里，我们综述了在理解调控这一关键细胞周期转变的分子机制方面取得的最新进展。
