表皮溶解毒素A的反应性丝氨酸残基。
The reactive serine residue of epidermolytic toxin A.
作者信息
Bailey C J, Smith T P
机构信息
Department of Biochemistry, Trinity College, Dublin, Ireland.
出版信息
Biochem J. 1990 Jul 15;269(2):535-7. doi: 10.1042/bj2690535.
Abstract
Comparison of amino acid sequence data suggested that there may be a functional relationship between the staphylococcal epidermolytic toxins and V8 proteinase. The hypothesis was tested by treating epidermolytic toxin with di-isopropyl phosphorofluoridate, which bound specifically at serine-195, the homologue of the active-site serine residue of V8 proteinase.
摘要
氨基酸序列数据的比较表明，葡萄球菌表皮溶解毒素与V8蛋白酶之间可能存在功能关系。通过用二异丙基氟磷酸酯处理表皮溶解毒素来验证这一假设，二异丙基氟磷酸酯特异性结合在丝氨酸-195处，该位点是V8蛋白酶活性位点丝氨酸残基的同源物。
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本文引用的文献
1
A circular-dichroism study of epidermolytic toxins A and B from Staphylococcus aureus.金黄色葡萄球菌表皮剥脱毒素A和B的圆二色性研究。
Biochem J. 1982 Jun 1;203(3):775-8. doi: 10.1042/bj2030775.
2
A comparative study of two serotypes of epidermolytic toxin from Staphylococcus aureus.金黄色葡萄球菌两种血清型表皮溶解毒素的比较研究。
Biochim Biophys Acta. 1980 Jul 24;624(1):111-20. doi: 10.1016/0005-2795(80)90230-5.
3
Toxins of Staphylococcus aureus.金黄色葡萄球菌毒素
Pharmacol Ther. 1982;19(1):55-106. doi: 10.1016/0163-7258(82)90042-0.
4
Fluorescein isothiocyanate-labeled casein assay for proteolytic enzymes.用于蛋白水解酶的异硫氰酸荧光素标记酪蛋白测定法。
Anal Biochem. 1984 Nov 15;143(1):30-4. doi: 10.1016/0003-2697(84)90553-0.
5
Purification and properties of an extracellular protease of Staphylococcus aureus.金黄色葡萄球菌一种细胞外蛋白酶的纯化及特性
J Biol Chem. 1972 Oct 25;247(20):6720-6.
6
Interaction of staphylococcal exfoliative toxin with concanavalin A.
Infect Immun. 1974 Dec;10(6):1260-5. doi: 10.1128/iai.10.6.1260-1265.1974.
7
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FEBS Lett. 1974 Sep 15;46(1):92-5. doi: 10.1016/0014-5793(74)80342-x.
8
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Nucleic Acids Res. 1987 Aug 25;15(16):6757. doi: 10.1093/nar/15.16.6757.
9
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10
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J Gen Microbiol. 1988 Mar;134(3):711-7. doi: 10.1099/00221287-134-3-711.
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