Laboratório de Micologia, Departamento de Microbiologia e Parasitologia, Instituto de Biologia, Universidade Federal de Pelotas (UFPel), Prédio 18, Sala 14, Campus Capão do Leão, Pelotas, RS, 96010-900, Brazil,
Mycopathologia. 2013 Oct;176(3-4):309-15. doi: 10.1007/s11046-013-9683-7. Epub 2013 Aug 7.
Pythium insidiosum is an oomycete, a fungal like microorganism, which infects mammals, causing pythiosis in animals and humans, especially in tropical and subtropical regions around the world. The treatment for this infection is very difficult, and therapeutic options commonly comprise surgery, immunotherapy and antimicrobial drugs. The present report describes the clinical healing of a dog with gastrointestinal pythiosis by treatment with a combination of antifungals and immunotherapy, as well as reviews the cases reported in the literature that used some type of therapy for canine pythiosis. A 2.5-year-old male beagle initially showed sporadic vomiting episodes, and this symptom became more frequent 5 months after the onset of clinical signs. Celiotomy procedure found thickness of the stomach wall extending to the pylorus and duodenum. A biopsy was performed, and the diagnosis of pythiosis was made by mycological, histopathological analyses and molecular identification. Therapy was based on an association of terbinafine plus itraconazole during 12 months and immunotherapy for 2.5 months. The healing of the dog reported here allows us to propose the use of immunotherapy associated with antifungal therapy to treat canine gastrointestinal pythiosis. However, additional studies should be performed on a larger number of patients to establish a standard treatment protocol for canine pythiosis.
腐霉病是一种卵菌，一种类似真菌的微生物，可感染哺乳动物，导致动物和人类的腐霉病，特别是在全球热带和亚热带地区。这种感染的治疗非常困难，治疗选择通常包括手术、免疫疗法和抗菌药物。本报告描述了一只患有胃肠道腐霉病的狗通过联合使用抗真菌药物和免疫疗法进行治疗的临床愈合情况，并回顾了文献中报道的一些用于治疗犬腐霉病的病例。一只 2.5 岁的雄性比格犬最初表现为间歇性呕吐发作，在出现临床症状 5 个月后，该症状变得更加频繁。剖腹手术发现胃壁从幽门延伸到十二指肠增厚。进行了活检，通过真菌学、组织病理学分析和分子鉴定做出了腐霉病的诊断。治疗基于特比萘芬联合伊曲康唑治疗 12 个月和免疫治疗 2.5 个月。这里报告的狗的愈合情况使我们能够提出将免疫疗法与抗真菌疗法联合用于治疗犬胃肠道腐霉病。然而，应该在更多的患者中进行更多的研究，以建立犬腐霉病的标准治疗方案。
