Kalpdev Arun, Saha Subhash Chander, Dhawan Veena
Department of Obstetrics & Gynecology, Post Graduate Institute of Medical Research and Education (PGIMER), Chandigarh, India.
Hypertens Pregnancy. 2011;30(4):447-56. doi: 10.3109/10641955.2010.507840. Epub 2010 Dec 21.
Oxidative stress could play a role in the development of preeclampsia. There is some evidence to suggest that vitamin C and E supplements can reduce the risk of the disorder. We hypothesized its beneficial role in a group of pregnant women with essential hypertension.
In this randomized controlled trial, we enrolled 50 pregnant women with essential hypertension. We assigned the women 1000 mg vitamin C and 400 IU natural vitamin E (RRR α tocopherol; n = 25), daily from the second trimester of pregnancy until delivery or no supplementation (n = 25). Our primary endpoint was development of superimposed preeclampsia, and main secondary endpoints were aggravation of hypertension, need for admission, need to increase antihypertensive drugs, and small size for gestational age (<fifth customized birthweight centile).
We analyzed 50 women who completed the study. The incidence of superimposed preeclampsia was similar in vitamin and control groups (8% [n = 2] vs 12% [n = 3], p = 1.000). Vitamin C and E supplementation also did not prevent aggravation of hypertension in group of women who took it (12% [n = 3] vs 32% [n = 8], p = 0.172). Small size for gestational age babies did not differ between groups (4% [n = 2] vs 6% [n = 3], p = 1.000).
Vitamin C and E supplementation does not prevent development of superimposed preeclampsia in women with essential hypertension. Our results did not show any significant benefit of vitamin supplementation. There was some trend in lessening of hypertensive complications of pregnancy. Our results failed to find any correlation between development of superimposed preeclampsia and oxidative stress.
氧化应激可能在子痫前期的发生发展中起作用。有证据表明补充维生素C和E可降低该病的风险。我们推测其对一组原发性高血压孕妇有益。
在这项随机对照试验中，我们纳入了50名原发性高血压孕妇。我们将这些女性分为两组，一组从妊娠中期至分娩每天服用1000毫克维生素C和400国际单位天然维生素E（RRRα生育酚；n = 25），另一组不进行补充（n = 25）。我们的主要终点是并发子痫前期的发生，主要次要终点是高血压加重、入院需求、增加降压药物的需求以及小于胎龄儿（<第五个定制出生体重百分位数）。
我们分析了50名完成研究的女性。维生素组和对照组并发子痫前期的发生率相似（8% [n = 2] 对12% [n = 3]，p = 1.000）。补充维生素C和E也未能预防服用该补充剂的女性组中高血压的加重（12% [n = 3] 对32% [n = 8]，p = 0.172）。两组间小于胎龄儿的情况无差异（4% [n = 2] 对6% [n = 3]，p = 1.000）。
补充维生素C和E不能预防原发性高血压女性并发子痫前期的发生。我们的结果未显示补充维生素有任何显著益处。在减轻妊娠高血压并发症方面有一些趋势。我们的结果未能发现并发子痫前期的发生与氧化应激之间存在任何关联。
