Australian School of Advanced Medicine, Macquarie University, 2 Technology Place, Sydney, NSW 2109, Australia.
Curr Eye Res. 2011 Jan;36(1):53-9. doi: 10.3109/02713683.2010.530731.
The amplitude of spontaneous retinal venous pulsations (SRVP) is known to be affected by intraocular pressure (IOP), retinal venous pressure, and intracranial pressure (ICP). This study characterized SRVPs adjacent to the disc and quantified changes in the amplitude of these pulsations during IOP manipulation in normal subjects.
The study included 12 subjects (40 ± 15, 4 females, 8 males). Baseline IOP (range 10-25 mmHg) was measured and SRVP recorded using the dynamic retinal vessel analyzer (DVA). IOP was lowered using aproclonidine 0.5% and measured every 15 min, followed by dynamic recording of SRVP. Two subjects were also tested with timolol 0.5%, and three were treated with a placebo drop. Mean amplitude of SRVP was determined within each sample at the same site. Blood pressure and heart rate were tracked continuously.
Amplitude of SRVP decreased in all subjects with reduction of IOP with aproclonidine and timolol. Mean SRVP amplitude was 8.5 ± 6 μm at baseline and reduced to 2.5 ± 1.8 μm after 45 min (p < 0.0001). IOP fell from 14.4 ± 2.6 mmHg to 10.2 ± 2.9 mmHg over the same period (p < 0.001). Venous diameter, blood pressure, and heart rate did not change significantly from the baseline. Analysis of waveforms showed a slight phase shift only (150 ± 78.5 ms, p = 0.93) between disc veins and adjacent retinal vein.
SRVPs in the peripapillary retina have similar waveform characteristics to those at the disc. SRVP amplitudes are reduced by manipulation of IOP downwards with pharmacological intervention. The relationship was consistent in all individuals tested for two classes of drugs and was independent of BP or heart rate changes.
已知自发视网膜静脉搏动（SRVP）的幅度受眼内压（IOP）、视网膜静脉压和颅内压（ICP）的影响。本研究对紧邻视盘的 SRVP 进行了特征描述，并定量分析了正常受试者在 IOP 操作过程中这些搏动幅度的变化。
该研究纳入了 12 名受试者（40±15 岁，4 名女性，8 名男性）。测量基础 IOP（范围 10-25mmHg），使用动态视网膜血管分析仪（DVA）记录 SRVP。使用 0.5%阿可乐定降低 IOP，每 15 分钟测量一次，随后进行 SRVP 动态记录。两名受试者还接受了 0.5%噻吗洛尔的测试，三名受试者接受了安慰剂滴注。在相同部位的每个样本中确定 SRVP 的平均幅度。连续跟踪血压和心率。
在所有接受阿可乐定和噻吗洛尔降低 IOP 的受试者中，SRVP 的幅度均降低。基础状态下 SRVP 平均幅度为 8.5±6μm，45 分钟后降至 2.5±1.8μm（p<0.0001）。在此期间，IOP 从 14.4±2.6mmHg 降至 10.2±2.9mmHg（p<0.001）。静脉直径、血压和心率与基线相比无明显变化。对波形进行分析仅显示出轻微的相位偏移（150±78.5ms，p=0.93），即视盘静脉和相邻视网膜静脉之间的相位偏移。
视盘周围视网膜的 SRVP 具有与视盘处相似的波形特征。通过药理学干预将 IOP 向下调节可降低 SRVP 幅度。这种关系在所有接受两种药物类别的个体中都是一致的，且与血压或心率变化无关。
