实验性高眼压下视网膜脉搏波速度的变化。
Alterations in retinal pulse wave velocity under experimental ocular hypertension.
机构信息
Department of Ophthalmology, University of Southern California, Los Angeles, CA, USA.
Department of Ophthalmology, University of Southern California, Los Angeles, CA, USA.
出版信息
Microvasc Res. 2023 Jul;148:104535. doi: 10.1016/j.mvr.2023.104535. Epub 2023 Apr 5.
Impairments of blood flow and autoregulation have been implicated in diabetic retinopathy and glaucoma. Thus, identifying biomarkers of retinal vascular compliance and regulatory capacity is of potential value for understanding the pathophysiology and evaluating onset or progression of disease. Pulse wave velocity (PWV) represents the speed of the pulse-propagated pressure wave within blood vessels and has shown promise as a marker of vascular compliance. The purpose of the current study was to report a method for comprehensive assessment of retinal PWV based on spectral analysis of pulsatile intravascular intensity waveforms and determine alterations due to experimental ocular hypertension. Retinal PWV was linearly related to vessel diameter. Increased retinal PWV was associated with elevated intraocular pressure. Retinal PWV has the potential to serve as a vasoregulation biomarker for investigating vascular factors that contribute to the development of retinal diseases in animal models.
血流和自动调节功能的损伤与糖尿病性视网膜病变和青光眼有关。因此，鉴定视网膜血管顺应性和调节能力的生物标志物对于理解病理生理学和评估疾病的发生或进展具有潜在的价值。脉搏波速度 (PWV) 代表血管内脉搏传播压力波的速度，已被证明是血管顺应性的标志物。本研究的目的是报告一种基于脉动血管内强度波形的频谱分析来综合评估视网膜 PWV 的方法，并确定由于实验性眼高压引起的变化。视网膜 PWV 与血管直径呈线性相关。视网膜 PWV 的增加与眼内压的升高有关。视网膜 PWV 有可能作为血管调节生物标志物，用于研究导致动物模型中视网膜疾病发展的血管因素。
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