Department of Biomedical Engineering, Brno University of Technology, Brno, Czech Republic.
Division of Clinical Behavioral Neuroscience, Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
Commun Biol. 2022 Jun 14;5(1):582. doi: 10.1038/s42003-022-03441-6.
Theoretical models of retinal hemodynamics showed the modulation of retinal pulsatile patterns (RPPs) by heart rate (HR), yet in-vivo validation and scientific merit of this biological process is lacking. Such evidence is critical for result interpretation, study design, and (patho-)physiological modeling of human biology spanning applications in various medical specialties. In retinal hemodynamic video-recordings, we characterize the morphology of RPPs and assess the impact of modulation by HR or other variables. Principal component analysis isolated two RPPs, i.e., spontaneous venous pulsation (SVP) and optic cup pulsation (OCP). Heart rate modulated SVP and OCP morphology (p < 0.05); age modulated SVP morphology (p < 0.05). In addition, age and HR demonstrated the effect on between-group differences. This knowledge greatly affects future study designs, analyses of between-group differences in RPPs, and biophysical models investigating relationships between RPPs, intracranial, intraocular pressures, and cardiovascular physiology.
视网膜血液动力学理论模型表明，心率（HR）可调节视网膜脉动模式（RPP），但这种生物学过程的体内验证和科学意义尚缺乏。这种证据对于结果解释、研究设计以及跨越各种医学专业应用的人类生物学（病理）生理建模都至关重要。在视网膜血液动力学视频记录中，我们描述了 RPP 的形态，并评估了 HR 或其他变量对其的调制作用。主成分分析分离出两种 RPP，即自发静脉搏动（SVP）和视杯搏动（OCP）。心率调节 SVP 和 OCP 的形态（p<0.05）；年龄调节 SVP 的形态（p<0.05）。此外，年龄和 HR 对组间差异有影响。这一知识极大地影响了未来的研究设计、RPP 组间差异的分析，以及研究 RPP 与颅内、眼内压和心血管生理学之间关系的生物物理模型。
