炔烃合成氮杂环的原子经济性方法。
An atom-economic synthesis of nitrogen heterocycles from alkynes.
机构信息
Department of Chemistry, Stanford University, Stanford, California 94305-5080, United States.
出版信息
J Am Chem Soc. 2011 Feb 2;133(4):740-3. doi: 10.1021/ja110117g.
Abstract
A robust route to 2,4-disubstituted pyrrole heterocycles relying upon a cascade reaction is reported. The reaction benefits from operational simplicity: it is air and moisture tolerant and is performed at ambient temperature. Control over the reaction conditions provides ready access to isopyrroles, 2,3,4-trisubstituted pyrroles, and 3-substituted pyrollidin-2-ones.
摘要
报告了一种依赖于级联反应的合成 2,4-二取代吡咯杂环的稳健方法。该反应具有操作简单的优点：它对空气和水分具有耐受性，可以在环境温度下进行。通过控制反应条件，可以轻松获得异吡咯、2,3,4-三取代吡咯和 3-取代吡咯烷-2-酮。
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