Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia, USA.
Org Lett. 2010 Mar 5;12(5):924-7. doi: 10.1021/ol9028385.
An unusual rhodium carbenoid approach for introduction of 4-substituted (Z)-pent-2-enoates into sterically encumbered pyrroles and indoles is described. These studies show that (Z)-vinylcarbenoids have a greater tendency than (E)-vinylcarbenoids to react at the vinylogous position of the carbenoid rather than at the carbenoid center.
描述了一种将 4-取代的(Z)-戊-2-烯酸酯引入空间位阻较大的吡咯和吲哚中的铑卡宾的不寻常方法。这些研究表明,(Z)-乙烯基卡宾比(E)-乙烯基卡宾更倾向于在卡宾的烯丙位而不是卡宾中心反应。