免疫抑制患者接受大剂量紫外线 A1（320-400nm）光疗后发生 Merkel 细胞癌：两例报告。

Merkel cell carcinoma arising in immunosuppressed patients treated with high-dose ultraviolet A1 (320-400 nm) phototherapy: a report of two cases.

机构信息

Department of Dermatology, University of Brescia, Azienda Spedali Civili, Brescia, Italy.

出版信息

Photodermatol Photoimmunol Photomed. 2010 Oct;26(5):263-5. doi: 10.1111/j.1600-0781.2010.00529.x.

DOI:10.1111/j.1600-0781.2010.00529.x

Abstract

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin. Though immunodeficiency is the most relevant risk factor, ultraviolet (UV) radiation is also involved, but as of yet we do not know the action spectrum, pattern or dose which would produce a dangerous exposure. A retrospective study of two immunosuppressed patients who developed MCC during, or soon after a treatment cycle with high dose UVA1 exposures was conducted, in order to understand wether repeated exposures to suberythemogenic UVA1 radiation may have a cancerogenic activity provoking MCC in immunosuppressed patients.

摘要

默克尔细胞癌（Merkel cell carcinoma，MCC）是一种侵袭性的皮肤神经内分泌肿瘤。免疫缺陷是最相关的危险因素，但紫外线（ultraviolet，UV）辐射也与之相关，然而我们目前尚不清楚会产生危险暴露的作用光谱、模式或剂量。我们对两名接受大剂量 UVA1 照射治疗周期中或之后发生 MCC 的免疫抑制患者进行了回顾性研究，目的是了解反复接受亚致死剂量 UVA1 辐射是否可能具有致癌活性，从而促使免疫抑制患者发生 MCC。