Yale University School of Medicine, Department of Psychiatry, 300 George St., New Haven, CT 06511, USA.
Pharmacol Biochem Behav. 2011 Mar;98(1):94-100. doi: 10.1016/j.pbb.2010.12.013. Epub 2010 Dec 21.
Marijuana (cannabis) is the most widely used illicit substance globally, and cannabis use is associated with a range of adverse consequences. Currently, no medications have been proven to be effective for the treatment of cannabis addiction. The goals of this study were to examine the safety and efficacy of a potential treatment medication, modafinil, in combination with oral ∆9-tetrahydrocannabinol (THC). Twelve male and female occasional cannabis users participated in an outpatient double-blind, placebo-controlled, crossover study. Across four sessions, participants were randomly assigned to a sequence of four oral treatments: (1) 400 mg modafinil+placebo, (2) 15 mg THC+placebo, (3) 400 mg modafinil+15 mg THC, or (4) placebo+placebo. Outcome measures included heart rate, blood pressure, performance on the Rapid Visual Information Processing (RVIP), and the Hopkins Verbal Learning Test (HVLT), and subjective measures. Oral THC increased heart rate, and produced increased subjective ratings of feeling "high" and "sedated," as well as increased ratings of euphoria. Modafinil alone increased the Profiles of Mood States (POMS) subscales of vigor and tension. These findings support the safety of modafinil in combination with THC. The effects of modafinil in combination with a range of doses of THC need to be determined in future studies.
大麻（大麻）是全球使用最广泛的非法物质，大麻的使用与一系列不良后果有关。目前，尚无药物被证明对治疗大麻成瘾有效。本研究的目的是研究一种潜在治疗药物莫达非尼与口服 ∆9-四氢大麻酚（THC）联合使用的安全性和有效性。12 名男性和女性偶尔使用大麻的参与者参加了一项门诊双盲、安慰剂对照、交叉研究。在四个疗程中，参与者被随机分配到四个口服治疗方案的序列之一：（1）400mg 莫达非尼+安慰剂，（2）15mg THC+安慰剂，（3）400mg 莫达非尼+15mg THC，或（4）安慰剂+安慰剂。结果测量包括心率、血压、快速视觉信息处理（RVIP）和霍普金斯词语学习测试（HVLT）的表现，以及主观测量。口服 THC 会增加心率，并导致更高的“兴奋”和“镇静”的主观评分，以及更高的快感评分。莫达非尼单独使用会增加情绪状态问卷（POMS）的活力和紧张度。这些发现支持莫达非尼与 THC 联合使用的安全性。需要在未来的研究中确定莫达非尼与不同剂量 THC 联合使用的效果。
