衰老肾脏中的高血压与血管生成：综述。

Hypertension and angiogenesis in the aging kidney: a review.

机构信息

Department of Physiology, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.

出版信息

Arch Gerontol Geriatr. 2011 May-Jun;52(3):e93-102. doi: 10.1016/j.archger.2010.11.032. Epub 2010 Dec 21.

DOI:10.1016/j.archger.2010.11.032

PMID:21176977

Abstract

With advanced aging, main components of the kidney are altered, including blood vessels, glomeruli and tubulointerstitium. Disruption in these 3 elements is interconnected and associated with several modifications, such as loss of kidney mass and systemic, metabolic and immunologic diseases. In this review we focus on renal blood vessels, the key role of hypertension and angiogenesis in the elderly kidney, the hemodynamic and molecular mechanisms underlying this aging process and the main factors involved. So far, the present data suggests a strong association between renal disease and hypertension and the impairment of regulatory mechanisms, such as angiogenesis in the aging kidney. The endothelium is a key player in vascular control and appears to be also disrupted in many compensatory functions (i.e., vasodilation). Perspectives for the management of the dysfunctional aging kidney are also addressed.

摘要

随着年龄的增长，肾脏的主要组成部分发生改变，包括血管、肾小球和肾小管间质。这三个元素的破坏是相互关联的，并与多种改变相关，如肾脏质量的损失以及系统性、代谢性和免疫性疾病。在这篇综述中，我们重点关注肾脏血管、高血压和血管生成在老年肾脏中的关键作用、这种衰老过程的血流动力学和分子机制以及涉及的主要因素。到目前为止，现有数据表明肾脏疾病与高血压之间存在很强的关联，以及调节机制（如肾脏血管生成）受损。内皮细胞是血管控制的关键参与者，在许多代偿功能（如血管舒张）中似乎也受到破坏。还讨论了功能失调的老年肾脏的处理方法。