Yabuki Akira, Yoneshige Shinichiro, Tanaka Shin, Tsujio Masashi, Mitani Sawane, Yamato Osamu
Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
J Vet Med Sci. 2014 Mar 1;76(2):277-80. doi: 10.1292/jvms.13-0431. Epub 2013 Oct 9.
In this study, age-dependent histological changes in the kidneys of Brown Norway rat, a strain useful for conducting aging research, were evaluated. Examination was performed at 3, 12, 18, 24 and 30 months of age. Sclerotic and hypertrophic changes of the glomeruli were observed, and quantitative scores of these changes persistently increased with age. A marginal increase in scores was observed for glomerular cystic changes and tubulointerstitial damage. Further, urothelial hyperplasia was observed in the renal papillae, particularly at 30 months of age. In conclusion, the findings of the present study demonstrate that the Brown Norway strain exhibits persistent, but mild progression of age-dependent renal histological changes.
在本研究中，对一种可用于开展衰老研究的品系——棕色挪威大鼠肾脏中随年龄变化的组织学改变进行了评估。在3、12、18、24和30月龄时进行检查。观察到肾小球的硬化和肥大改变，并且这些改变的定量评分随年龄持续增加。肾小球囊性改变和肾小管间质损伤的评分有轻微增加。此外，在肾乳头中观察到尿路上皮增生，特别是在30月龄时。总之，本研究结果表明，棕色挪威品系表现出随年龄增长的肾脏组织学改变持续但轻微的进展。
