BHF Centre of Research Excellence, Division of Cardiovascular Medicine, King's College London, SE5 9NU, UK.
Curr Opin Cell Biol. 2011 Feb;23(1):47-54. doi: 10.1016/j.ceb.2010.11.006. Epub 2010 Dec 20.
Like other spectrin repeat proteins, nesprins co-ordinate and maintain cellular architecture by linking membranous organelles to the cytoskeleton. However nuclear envelope (NE) nesprins, uniquely hardwire the nuclear lamina to the cytoskeleton and molecular motors. Emerging evidence suggests that nesprins also form a continuous network linking the plasma membrane to the NE that potentially translates mechanical stimuli into nuclear reorganisation. Surprisingly, this network is also essential for cytoskeletal organisation and its disruption has dramatic effects on nuclear migration, centrosomal positioning, focal adhesion maturation and cell motility. Herein we review recent advances in our understanding of how nesprins couple to various filamentous systems within the cell and emphasise the importance of both KASH and KASH-less nesprin isoforms in these interactions.
与其他 spectrin 重复蛋白一样，nesprins 通过将膜细胞器与细胞骨架连接起来，协调和维持细胞结构。然而，核膜 (NE) nesprins 通过将核层与细胞骨架和分子马达独特地硬连线连接起来。新出现的证据表明，nesprins 还形成了一个将质膜连接到 NE 的连续网络，该网络可能将机械刺激转化为核重组。令人惊讶的是，这个网络对于细胞骨架的组织也是必不可少的，它的破坏对核迁移、中心体定位、焦点黏附成熟和细胞运动有巨大影响。本文综述了我们对 nesprins 如何与细胞内各种丝状系统偶联的理解的最新进展，并强调了 KASH 和 KASH-less nesprin 同种型在这些相互作用中的重要性。
