Alshemmari S, Sajnani K P, Refaat S, Albassami A
Department of Medicine, Kuwait University, State of Kuwait .
Gulf J Oncolog. 2011 Jan(9):20-6.
Hodgkin lymphoma (HL) comprises about 25% of all malignant nodal lymphomas worldwide. Incidence of HL has been increasing in many countries around the world, in the western countries in particular. Cancer incidence variations in different ethnic groups in the same country can lead to some important information about the search of etiological factors. Some researchers found an association between ethnicity and increased risk of HL. In this study, we evaluated the epidemiologic and clinical characteristics of patients with HL and the HL subtypes in Kuwait who were diagnosed between 1998 and 2006 and we analyzed the changes in the incidence of HL over time based on age, sex, and ethnicity.
The Kuwait Cancer Control Center is a tertiary referral hospital and the only cancer hospital in the entire state of Kuwait. We identified 293 patients who were newly diagnosed with HL by histopathology between January 1, 1998, and December 31, 2006, at the Kuwait Cancer Control Center. Incidence data were crossvalidated with the population-based Cancer Registry of Kuwait. Clinical data were obtained by reviewing the patients' medical records.
The median age at diagnosis was 39 years (range, 10-85 years) for patients with cHL and 36 years (range, 14-51 years) for patients with NLPHL. The age-adjusted incidence rate was 2.1 cases (range, 1.2-2.9) per 100,000 people per year in the period between 1998 and 2006. NLPHL and cHL were predominant in men with a male to female ratio of 2:1. However, the mean annual percentage change in HL incidence among Kuwaiti patients and non-Kuwaiti patients per year showed unexplained higher percentage in females both Kuwaiti and non-Kuwaiti. cHL comprised 92.5% of all HL cases and NLPHL comprised 7.5%. Nodular sclerosis was the predominant histologic subtype of cHL (58.9%), whereas mixed cellularity was the second most frequent histologic subtype of cHL, (25.9%).
Although the incidence of HL was slightly lower in Kuwait than the worldwide incidence; it was similar to Asian descent population. Incidence of HL varied in the same country among different ethnic subgroups. The mean annual percentage change increased in Kuwaiti and non-Kuwaiti females.
霍奇金淋巴瘤（HL）约占全球所有恶性淋巴结淋巴瘤的25%。全球许多国家，尤其是西方国家，HL的发病率一直在上升。同一国家不同种族群体的癌症发病率差异可以为寻找病因提供一些重要信息。一些研究人员发现种族与HL风险增加之间存在关联。在本研究中，我们评估了1998年至2006年间在科威特被诊断为HL的患者及其HL亚型的流行病学和临床特征，并根据年龄、性别和种族分析了HL发病率随时间的变化。
科威特癌症控制中心是一家三级转诊医院，也是科威特全国唯一的癌症医院。我们确定了1998年1月1日至2006年12月31日期间在科威特癌症控制中心通过组织病理学新诊断为HL的293例患者。发病率数据与科威特基于人群的癌症登记处进行了交叉验证。通过查阅患者的病历获得临床数据。
经典型霍奇金淋巴瘤（cHL）患者的诊断中位年龄为39岁（范围10 - 85岁），结节性淋巴细胞为主型霍奇金淋巴瘤（NLPHL）患者为36岁（范围14 - 51岁）。1998年至2006年期间，年龄调整后的发病率为每10万人每年2.1例（范围1.2 - 2.9）。NLPHL和cHL在男性中占主导，男女比例为2:1。然而，科威特患者和非科威特患者中HL发病率的年平均变化百分比显示，科威特和非科威特女性的这一比例均出现了无法解释的较高增长。cHL占所有HL病例的92.5%，NLPHL占7.5%。结节硬化是cHL的主要组织学亚型（58.9%），而混合细胞型是cHL的第二常见组织学亚型（25.9%）。
尽管科威特的HL发病率略低于全球发病率，但与亚洲血统人群相似。同一国家内不同种族亚组的HL发病率有所不同。科威特和非科威特女性的年平均变化百分比有所增加。
