Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.
作者信息
Bell Karen F, Al-Mubarak Bashayer, Fowler Jill H, Baxter Paul S, Gupta Kunal, Tsujita Tadayuki, Chowdhry Sudhir, Patani Rickie, Chandran Siddharthan, Horsburgh Karen, Hayes John D, Hardingham Giles E
出版信息
Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):E1-2; author reply E3-4. doi: 10.1073/iti0111108. Epub 2010 Dec 21.
Abstract
摘要
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Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.轻度氧化应激激活星形胶质细胞中的Nrf2，这有助于神经保护性缺血预处理。
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本文引用的文献
1
Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway.通过一种不依赖 Nrf2 的途径，控制酶产生的星形胶质细胞过氧化氢可保护神经元免受氧化应激。
Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17385-90. doi: 10.1073/pnas.1003996107. Epub 2010 Sep 20.
2
Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.神经保护剂Nrf2激活剂3H-1,2-二硫杂环戊烯-3-硫酮对硫氧还蛋白表达的诱导及过氧化物还原酶过度氧化的减少
J Neurochem. 2008 Oct;107(2):533-43. doi: 10.1111/j.1471-4159.2008.05648.x. Epub 2008 Sep 16.
3
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses.突触N-甲基-D-天冬氨酸受体活性增强内在抗氧化防御能力。
Nat Neurosci. 2008 Apr;11(4):476-87. doi: 10.1038/nn2071. Epub 2008 Mar 23.
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Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells.环境信号调节来自人类胚胎干细胞的神经干细胞的谱系选择和时间成熟。
Brain. 2007 May;130(Pt 5):1263-75. doi: 10.1093/brain/awm070.
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Measurement of striatal H2O2 by microdialysis following global forebrain ischemia and reperfusion in the rat: correlation with the cytotoxic potential of H2O2 in vitro.大鼠全脑缺血再灌注后通过微透析法测量纹状体过氧化氢：与过氧化氢体外细胞毒性潜能的相关性
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