Department of Microbiology and Immunology and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Sci Signal. 2010 Dec 21;3(153):pe50. doi: 10.1126/scisignal.3153pe50.
It has been long surmised that the strength of stimulation of the T cell receptor (TCR) determines the robustness of TCR-mediated signaling and the magnitude of a T cell response. However, it is becoming evident that the signal from the TCR develops over time to approach its steady-state, affinity-determined maximal extent and that variations in this time have a substantial effect on the responsiveness of T cells. Here, I discuss data that show that the kinetics of signal propagation in various segments of the TCR signaling network can influence the spatiotemporal regulation of the effector functions of T cells and the quality of the T cell response.
长期以来，人们一直推测 T 细胞受体 (TCR) 的刺激强度决定了 TCR 介导的信号转导的稳健性以及 T 细胞反应的幅度。然而，现在越来越明显的是，TCR 的信号随着时间的推移而发展，趋近于其稳态、亲和力决定的最大程度，而这种时间上的变化对 T 细胞的反应性有很大的影响。在这里，我讨论了一些数据，这些数据表明 TCR 信号转导网络的各个部分中信号传播的动力学可以影响 T 细胞效应功能的时空调节以及 T 细胞反应的质量。
