Brambilla F, Maggioni M, Ferrari E, Scarone S, Catalano M
Psychoendocrine Clinic, Ospedale Psichiatrico Pini, Milan, Italy.
Psychiatry Res. 1990 Jun;32(3):229-39. doi: 10.1016/0165-1781(90)90028-4.
Baseline follicle stimulating hormone (FSH) and luteinizing hormone (LH) plasma levels and their responses to luteinizing hormone releasing hormone (LHRH) stimulation were investigated in 72 patients who met Research Diagnostic Criteria for affective disorders and in 72 healthy volunteers. Fifty-six patients were examined during a depressive phase and 16 during a normothymic phase. LH-FSH basal levels were significantly lower in postmenopausal depressed and normothymic women than in controls. In fertile women and men, concentrations of the two gonadotropins were also lower in patients than in controls, but the phenomenon did not generally reach statistical significance. LHRH-induced LH rises were lower in postmenopausal and fertile depressed and normothymic women than in controls, while FSH rises were reduced only in postmenopausal depressive women in both depressed and normothymic phases. The impairment underlying the gonadotropin secretory deficiency remains to be elucidated.
对72名符合情感障碍研究诊断标准的患者和72名健康志愿者的基础促卵泡生成素（FSH）和促黄体生成素（LH）血浆水平及其对促黄体生成素释放激素（LHRH）刺激的反应进行了研究。56名患者在抑郁期接受检查，16名在心境正常期接受检查。绝经后抑郁和心境正常的女性的LH - FSH基础水平显著低于对照组。在育龄女性和男性中，患者体内这两种促性腺激素的浓度也低于对照组，但这种现象一般未达到统计学意义。绝经后和育龄期抑郁及心境正常的女性中，LHRH诱导的LH升高低于对照组，而FSH升高仅在绝经后抑郁女性的抑郁期和心境正常期均降低。促性腺激素分泌不足的潜在损伤仍有待阐明。
