Bradley Patrick J, Bradley Paula T, Olsen Kerry D
Department ORL-HNS, University Hospitals Nottingham, Queens Medical Centre Campus, UK.
Curr Opin Otolaryngol Head Neck Surg. 2011 Apr;19(2):92-8. doi: 10.1097/MOO.0b013e328342b9b4.
Parapharyngeal space (PPSp) tumours are uncommon and hence the 'generalist expertise' for diagnosis and treatment is limited. Recent improvements in radiology and cytopathology mean the likely diagnosis is more certain and hence the recommended surgical treatment can be more definitive.
A wide spectrum of primary pathologies are reported to involve the PPSp; the majority (80%) are benign neoplasms. Radiological imaging, computed tomography (CT) and MRI, with diagnostic fine needle aspiration cytology (FNAC), have continued to increase preoperative diagnostic accuracy. Thus, it is easier to identify the patients whose external surgery may rarely require a mandibulotomy. Only highly selected cases can be safely excised via a transoral approach.
All tumours of the PPSp require accurate diagnosis, using modern diagnostic imaging and FNAC. Surgery, in most cases, remains the treatment of choice. Many neurogenic tumours and paragangliomas can be observed in elderly patients. The optimum surgical approach for complete excision needs to be selected on an individual basis. Each patient must be adequately informed of the associated morbidity and possible complications, likelihood of cure and the risk of tumour recurrence - short and long term. Most tumours can be excised safely, and with low risk of recurrence and short hospitalization, with a cervical-parotid approach.
咽旁间隙(PPSp)肿瘤并不常见,因此诊断和治疗方面的“全科专业知识”有限。放射学和细胞病理学的最新进展意味着更有可能明确诊断,从而使推荐的手术治疗更具确定性。
据报道,多种原发性病理情况可累及PPSp;大多数(80%)为良性肿瘤。放射学成像、计算机断层扫描(CT)和磁共振成像(MRI)以及诊断性细针穿刺细胞学检查(FNAC)持续提高了术前诊断准确性。因此,更容易识别出那些很少需要下颌骨切开术进行外部手术的患者。只有经过严格挑选的病例才能通过经口途径安全切除。
所有PPSp肿瘤都需要使用现代诊断成像和FNAC进行准确诊断。在大多数情况下,手术仍然是首选治疗方法。许多神经源性肿瘤和副神经节瘤在老年患者中可以观察。需要根据个体情况选择完整切除的最佳手术方法。必须充分告知每位患者相关的发病率和可能的并发症、治愈的可能性以及肿瘤复发的风险——短期和长期风险。大多数肿瘤可以通过颈腮腺入路安全切除,复发风险低且住院时间短。