Comper W D, Zamparo O
Department of Biochemistry, Monash University, Clayton, Vic., Australia.
Biochem J. 1990 Aug 1;269(3):561-4. doi: 10.1042/bj2690561.
The major hydrodynamic properties of the connective-tissue polysaccharides are those that describe polysaccharide-water interaction as embodied in their osmotic-pressure and hydraulic-conductivity properties. This study shows that, for polysaccharides such as chondroitin sulphate, hyaluronate and the heparin-like polysaccharides, their hydrodynamic properties depend primarily on the presence of the uronic residue and the nature of the glycosidic linkage. Other parameters such as the degree of N-acetylation and sulphation were found not to influence these properties to any great extent. These studies particularly delineate structural-functional aspects of the connective-tissue polysaccharides in terms of their primary structure.
结缔组织多糖的主要流体动力学性质是那些描述多糖与水相互作用的性质,体现在它们的渗透压和水力传导率特性中。这项研究表明,对于诸如硫酸软骨素、透明质酸盐和类肝素多糖等多糖来说,它们的流体动力学性质主要取决于糖醛酸残基的存在以及糖苷键的性质。其他参数,如N-乙酰化程度和硫酸化程度,并未发现对这些性质有很大影响。这些研究特别从结缔组织多糖的一级结构方面描绘了其结构-功能关系。