Yoshimura Reiji, Ikenouchi-Sugita Atsuko, Hori Hikaru, Umene-Nakano Wakako, Hayashi Kenji, Katsuki Asuka, Ueda Nobuhisa, Nakamura Jun
Department of Psychiatry, University of Occupational and Environmental Health.
Seishin Shinkeigaku Zasshi. 2010;112(10):982-5.
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has been linked to the viability of neurons in brain circuits that regulate emotion, memory, learning, sleep, and appetite. BDNF has been most extensively studied in relation to depression. Depressed patients show reduced levels of hippocampal and cortical BDNF in postmortem studies. Recently, to the best of our knowledge, there are at least three meta-analyses regarding blood BDNF levels in depressed patients, suggesting that blood BDNF levels are decreased in depressive state, and those are recovered after treatment with biological treatments such as antidepressants, ECT, and rTMS. From these findings into account, it is possible that blood (plasma and serum) BDNF level is a biological marker for depressive state. We have recently demonstrated that a significantly negative correlation was observed between the HAMD scores and serum BDNF levels. In addition, responders to fluvoxamine, paroxetine, milnacipran, and sertraline all increased serum BDNF levels. Blood BDNF levels did not distinguish between responders and remitters to the treatment. In conclusion, blood BDNF levels partially reflect those in the brain, and there is also strong and consistent evidence indicating that these levels normalize following the biological intervention for depression.
脑源性神经营养因子（BDNF）是一种神经营养蛋白，与调节情绪、记忆、学习、睡眠和食欲的脑回路中神经元的存活有关。BDNF在抑郁症方面得到了最广泛的研究。在尸检研究中，抑郁症患者海马体和皮质中的BDNF水平降低。最近，据我们所知，至少有三项关于抑郁症患者血液BDNF水平的荟萃分析，表明抑郁状态下血液BDNF水平降低，而在接受抗抑郁药、ECT和rTMS等生物治疗后会恢复。考虑到这些发现，血液（血浆和血清）BDNF水平有可能是抑郁状态的生物学标志物。我们最近证明，汉密尔顿抑郁量表（HAMD）评分与血清BDNF水平之间存在显著的负相关。此外，氟伏沙明、帕罗西汀、米氮平、舍曲林的有效应答者血清BDNF水平均升高。血液BDNF水平无法区分治疗的有效应答者和缓解者。总之，血液BDNF水平部分反映了大脑中的水平，也有强有力且一致的证据表明，在对抑郁症进行生物干预后，这些水平会恢复正常。
