Wang Hongzhi, Pang Xiaofeng, Wang Aihua
Biological Electro Magnetic and Bioelectronic Technological Key Laboratory of Sichuan Province, College of Life science and Technology, Electron Scientific and Technological University, Chengdu 610054, China.
Zhongguo Yi Liao Qi Xie Za Zhi. 2010 Sep;34(5):326-9.
Since the bacteria metabolites in the process of growth and reproduction of can lower the resistivity characteristics of the medium, the electrical impedance method can develop a rapid detection device of bacterial drug sensitivity. The device consists of micro-organisms impedance sensors, computer systems, signal generator, resistance Anti-detection circuit, the time allocation controller, constant temperature incubator and auxiliary circuits and other components. It measures the electrical impedance of the medium, and bacteria in the culture period to obtain the impedance value of the monitor into the impedance curve. Drug sensitivity of bacteria can be determined, using this form of differential impedance curve. This detection device significantly shortened the time of bacterial drug susceptibility testing, achieving rapid drug susceptibility testing of clinical medicine, drug susceptibility testing automation and intelligence.
由于细菌在生长繁殖过程中的代谢产物会降低培养基的电阻特性，因此电阻抗法可研制细菌药敏快速检测装置。该装置由微生物阻抗传感器、计算机系统、信号发生器、电阻抗检测电路、时间分配控制器、恒温培养箱及辅助电路等部件组成。它测量培养基的电阻抗，并在细菌培养期间获取监测的阻抗值绘制成阻抗曲线。利用这种形式的微分阻抗曲线可确定细菌的药敏性。这种检测装置显著缩短了细菌药敏试验的时间，实现了临床医学药敏试验的快速化、药敏试验自动化和智能化。
