Wang Wan-tie, Hao Mao-lin, Wang Fang-yan, Ni Shi-rong, Song Zhang-juan, Xie Ke-jian, Fang Zhou-xi
Department of Pathophysiology, Wenzhou Medical College, China.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007 May;23(2):134-7.
To study the effect of ligustrazine (LGT) and L-arginine(L-Arg)on function of mitochondria in myocardium after myocardial ischemia/reperfusion injury (MI/RI).
50 rabbits were randomly divided into five groups (n=10): Control group(A), MI/R group(B), MI/R + LGT group (C), MI/R+ L-Arg group (D), MI/R+ LGT + L-Arg group (E). The mitochondrial respiratory function, Ca2+ concentration ([Ca2+]m), malondialdehyde (MDA) content and superoxide dismutase (SOD) activity were deter mined. Meanwhile, the contents of ATP and EC in the myocardial tissue were measured, respectively.
It was found that mitochondrial respiratory control rate (RCR), state 3 (ST3), SOD in C, D, E group were higher than those of B group, state 4 (ST4), [Ca2+]m, MDA were lower than those of B group, ATP and EC levels of myocardial tissue were higher than those in B group; and there were not significant differences between E and A group of above.
LGT and IL-Arg can improve function of mitochondria in myocardium after ischemia/reperfusion injury of myocardium in rabbits by decreasing oxygen free radical level and Ca" overload in the mitochondria.
研究川芎嗪（LGT）和L-精氨酸（L-Arg）对心肌缺血/再灌注损伤（MI/RI）后心肌线粒体功能的影响。
将50只家兔随机分为5组（n = 10）：对照组（A组）、MI/R组（B组）、MI/R + LGT组（C组）、MI/R + L-Arg组（D组）、MI/R + LGT + L-Arg组（E组）。测定线粒体呼吸功能、Ca2+浓度（[Ca2+]m）、丙二醛（MDA）含量和超氧化物歧化酶（SOD）活性。同时，分别测定心肌组织中ATP和EC的含量。
发现C、D、E组线粒体呼吸控制率（RCR）、状态3（ST3）、SOD高于B组，状态4（ST4）、[Ca2+]m、MDA低于B组，心肌组织ATP和EC水平高于B组；上述指标E组与A组之间无显著差异。
LGT和L-Arg可通过降低氧自由基水平和线粒体Ca2+超载来改善家兔心肌缺血/再灌注损伤后心肌线粒体功能。
