[参附注射液对心肌缺血/再灌注损伤后血流动力学及心肌酶的保护作用] （你提供的英文原文有语法错误，正确的应该是The protection of Shenfu injections on hemodynamics and myocardial enzyme after myocardial ischemia/reperfusion injury ）

[The protective of Shenfu injections on hemodynamics and myocardial enzyme after myocardial ischemia/reperfusion injury].

作者信息

Wang Zhen-Fu

机构信息

Medical School of Hubei Institute for Nationalities, Enshi 445000, China.

出版信息

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011 May;27(2):155-7.

PMID:21845859

Abstract

OBJECTIVE

To study the protective effect of Shenfu (Chinese traditional medicine) injections on myocardial ischemia/reperfusion (I/R) injury in rabbits.

METHODS

Thirty rabbits were divided into three groups (n = 10) randomly: control group, myocardial ischemia/ reperfusion group (MI/RI) and Shenfu injections extract group, three groups of rabbits were fed respectively with standard diet. After giving medicine 10 minutes, the myocardial ischemia/reperfusion injury animal model was established by ligaturing rabbits left ventricutar branch of coronary artery, and observing the changes of enzyme/hemodynamics during myocardial ischemia/reperfusion.

RESULTS

In model group myocardial function of shrink went down, the amount of malondialdehyde (MDA) was higher, the activity of superoxide dismutase (SOD), glutathine peroxidease (GSH-Px), Na(+) -K(+) -ATP and Ca(2+) -ATP were lower, lactic dehydrogenase (LDH) and creatine kinase(CK) were released compared with those in model group. Shenfu injections could recover left ventricular systolic pressure (LVSP) and +/- dp/dt(max), decrease left ventricular end-diastolic pressure(LVEDP), inhibit the increasing of MDA, LDH and CK, and increase the activaty of SOD, GSH-PX, Na(+) -K(+) -ATP and Ca(2+) -ATP.

CONCLUSION

Shenfu injections can obviously protect myocardial ischemia/reperfusion injury.

摘要

目的

研究参附（中药）注射液对家兔心肌缺血/再灌注（I/R）损伤的保护作用。

方法

30只家兔随机分为3组（n = 10）：对照组、心肌缺血/再灌注组（MI/RI）和参附注射液组，3组家兔均给予标准饮食。给药10分钟后，通过结扎家兔冠状动脉左室支建立心肌缺血/再灌注损伤动物模型，并观察心肌缺血/再灌注期间酶/血流动力学的变化。

结果

模型组心肌收缩功能下降，丙二醛（MDA）含量升高，超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、Na(+) -K(+) -ATP酶和Ca(2+) -ATP酶活性降低，乳酸脱氢酶（LDH）和肌酸激酶（CK）释放。与模型组相比，参附注射液可恢复左心室收缩压（LVSP）和±dp/dt(max)，降低左心室舒张末期压力（LVEDP），抑制MDA、LDH和CK的升高，并提高SOD、GSH-PX、Na(+) -K(+) -ATP酶和Ca(2+) -ATP酶的活性。