Wu Li-Ying, Liu Wei, Ding Ai-Shi, Wang Fu-Zhuang, Fan Ming
Department of Neurobiology, Institute of basic Medical Sciences, Academy of Military Medical Sciences, China.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2002 Feb;18(1):30-3.
To investigate the relationship between enhanced anoxic tolerance induced by hypoxic preconditioning and Na+, K+ currents.
After hypoxic preconditioning and acute anoxia the I(Na), I(K) were measured in cultured hypothalamic cells by patch-clamp whole cell recording technique.
The amplification of Na+ currents did not been significantly changed, but the amplification of K+ currents was in hypoxic preconditioning neurons; acute anoxia lead to the inhibition of Na+, K+ currents in the two groups, while Na+, K+ currents in non-preconditioned control group were inhibited severity than hypoxic preconditioning group.
It is presumed enhanced anoxia tolerance induced by hypoxic preconditioning may be related to the opening of K+ channels.
