[通过超声心动图值评估雄性Balb/c小鼠的心脏结构和功能]
[Assessment of cardiac structure and function by echocardiographic values for male Balb/c mice].
作者信息
Ma Ji-zheng, Tang Xiao-xia, Zhu Shu-shu, Wu Heng-fang, Chen Xiang-jian, Xu Di, Yang Di, Zhang Ji-nan
机构信息
Institute of Cardiovascular Disease, the First Affliated Hospital of Naning Medical University, Naning 210029, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007 Nov;23(4):390-3.
AIM
To assess the parameters of cardiac structure and function of male Balb/c mice by the echocardiography.
METHODS
A total of 27 male Balb/c mice (from five to seven week old) were examined with a 13-MHz transthoracic linear-array transducer, hearts were removed from mice anesthetized with Nembutal, and the left ventricular (LV) mass were weighed.
RESULTS
Complete 2-dimensional echocardiography for cardiac structure and function were obtained. Hemodynamic parameters were recorded. A correlation existed between LV weight (x) and echocardiographic LV mass (y) with the 2D) guided M-mode method: y = 1.15x + 3.26, (r = 0.80).
CONCLUSION
Echocardiography appears to be a promising approach for noninvasively assessing LV mass and function in mice.
目的
通过超声心动图评估雄性Balb/c小鼠的心脏结构和功能参数。
方法
使用13MHz经胸线性阵列换能器对27只雄性Balb/c小鼠（5至7周龄）进行检查，从小鼠体内取出用戊巴比妥麻醉的心脏，并对左心室（LV）质量进行称重。
结果
获得了完整的二维超声心动图以评估心脏结构和功能。记录了血流动力学参数。采用二维引导M型方法，左心室重量（x）与超声心动图左心室质量（y）之间存在相关性：y = 1.15x + 3.26，（r = 0.80）。
结论
超声心动图似乎是一种有前景的非侵入性评估小鼠左心室质量和功能的方法。
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