[菊米提取物抗心律失常作用的实验研究]
[Experimental studies on antiarrhythmic effect of jumi extraction].
作者信息
Xu Ce, Ye Ting-mei, Zhu Li, Chen Ying-ying, Shen Yue-liang
机构信息
Department of Physiology, School of Medicine, Zhejiang University, Hangzhou 310006, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007 Nov;23(4):399-402.
AIM
To investigate the antiarrhythmic effect of jumi (JM) extraction.
METHODS
The conventional antiarrhythmic methods were used.
RESULTS
Administration of JM extraction reduced the occurrence of ventricular fibrillation induced by chloroform in a dose-dependent manner in mice. Quinidine significantly decreased the number of ventricular premature beats and ventricular tachycardia, shortened the duration of arrhythmia in aconitine-treated rats. But JM extraction had no effect on aconitine-induced arrhythmia. Compared with control, arrhythmia score was lower in ischemia/reperfusion rats which pretreated with 2.0 g/kg of JM extraction.
CONCLUSION
JM extraction has obvious protection effects in chloroform- and ischemia-induced arrhythmia, but has no effect in aconitine-induced arrhythmia.
目的
研究菊米（JM）提取物的抗心律失常作用。
方法
采用常规抗心律失常方法。
结果
给予JM提取物可使小鼠氯仿诱导的室颤发生率呈剂量依赖性降低。奎尼丁显著减少乌头碱处理大鼠的室性早搏和室性心动过速数量，缩短心律失常持续时间。但JM提取物对乌头碱诱导的心律失常无作用。与对照组相比，用2.0 g/kg JM提取物预处理的缺血/再灌注大鼠心律失常评分较低。
结论
JM提取物对氯仿和缺血诱导的心律失常有明显保护作用，但对乌头碱诱导的心律失常无作用。
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