Li D Q, Kuang A K, Ding T, Chen J L, Xu M Y
Shanghai Institute of Endocrinology, Shanghai Second Medical University.
Chin Med J (Engl). 1990 May;103(5):355-8.
The clinical implications of nuclear T3R alterations of circulating lymphocytes in hyperthyroidism, hypothyroidism and nonthyroidal diseases were investigated. Nuclear T3R in lymphocytes was determined by radio-ligand binding analysis. The results showed that in hyper- and hypothyroid patients the nuclear affinity (Ka) for T3 was similar to that of normal subjects. In hyperthyroidism nuclear T3 maximal binding capacity (MBC) was unaltered, whereas in hypothyroidism the MBC was significantly increased. In the patients with diabetes mellitus, chronic renal failure and hepatic cirrhosis, the nuclear T3R MBC of lymphocytes was about 1.5-1.6 times of the normal controls. It was concluded that there existed hormonal regulation of nuclear T3R, and up-regulation was seen in hypothyroidism and low T3 syndrome.
研究了甲状腺功能亢进、甲状腺功能减退及非甲状腺疾病中循环淋巴细胞核甲状腺激素受体（T3R）改变的临床意义。采用放射性配体结合分析法测定淋巴细胞中的核T3R。结果显示，甲状腺功能亢进和减退患者的T3核亲和力（Ka）与正常受试者相似。甲状腺功能亢进时核T3最大结合容量（MBC）无变化，而甲状腺功能减退时MBC显著增加。糖尿病、慢性肾功能衰竭和肝硬化患者淋巴细胞的核T3R MBC约为正常对照的1.5 - 1.6倍。结论是存在核T3R的激素调节，甲状腺功能减退和低T3综合征中可见上调。
