Li D Q, Kuang A K, Ding T
Zhonghua Nei Ke Za Zhi. 1989 May;28(5):286-9, 315.
The relationship between nuclear receptors and thyroid function state has not been elucidated. We have determined the circulating lymphocyte nuclear T3R in normal subjects, in patients with hyper-and hypothyroidism and in hypothyroid patients on thyroid hormone substitution treatment, with 10 cases in each group. In hyperthyroid and hypothyroid patients, the nuclear affinity (Kd) for T3 was similar to that of normal subjects. In hyperthyroidism nuclear T3 MBC was unaltered, whereas in hypothyroidism the MBC was significantly increased to 8.06 +/- 0.80 fmol/micrograms DNA, being 2.1 times that of the control group. In hypothyroid patients treated with 90-120 mg desiccated thyroid extract daily the nuclear MBC was 4.34 +/- 0.72 fmol/micrograms DNA, being not different from that observed in euthyroid subjects. It was found that the nuclear T3 MBC was negatively correlated with serum levels of T3, T4, FT3, FT4 and rT3, but positively correlated with serum TSH concentration in hypothyroid patients. These results indicate hormonal modulation of the nuclear T3R which exhibits up regulation in hypothyroidism. The increase in nuclear T3R number might reflect a compensatory mechanism to the decreased serum concentrations of thyroid hormones.
核受体与甲状腺功能状态之间的关系尚未阐明。我们测定了正常受试者、甲状腺功能亢进和减退患者以及接受甲状腺激素替代治疗的甲状腺功能减退患者外周血淋巴细胞核T3受体，每组10例。甲状腺功能亢进和减退患者的T3核亲和力（Kd）与正常受试者相似。甲状腺功能亢进时核T3 MBC未改变，而甲状腺功能减退时MBC显著增加至8.06±0.80 fmol/μg DNA，为对照组的2.1倍。每日服用90 - 120mg干燥甲状腺提取物治疗的甲状腺功能减退患者，其核MBC为4.34±0.72 fmol/μg DNA，与甲状腺功能正常受试者无差异。发现在甲状腺功能减退患者中，核T3 MBC与血清T3、T4、FT3、FT4和rT3水平呈负相关，但与血清TSH浓度呈正相关。这些结果表明甲状腺激素对核T3受体有调节作用，在甲状腺功能减退时表现为上调。核T3受体数量的增加可能反映了对血清甲状腺激素浓度降低的一种代偿机制。
