Lu G
First Teaching Hospital, Beijing Medical University.
Zhonghua Yi Xue Za Zhi. 1993 Sep;73(9):517-9, 573.
Using radioligand binding assay of receptors, we studied the changes of T3 receptors in circulating lymphocytes in 20 normal persons and 43 diabetic patients with or without low T3. The mean value of serum T3 and FT3 was significantly decreased in all diabetic patients compared with that of normal controls. The concentration of serum T3 was negatively correlated with fasting blood glucose level. The serum rT3 was clearly increased in patients with low T3. The serum T4, FT4, FT4 I and TSH were normal in all patients The maximal binding capacity (MBC) of circulating lymphocyte T3 receptors which was negatively correlated with the serum T3 concentrations was obviously elevated in patients with diabetes mellitus. It was still higher in patients with low T3 than in patients with normal T3, whereas the affinity of receptor was not changed. In conclusion, the increment of T3 receptor binding capacity reflects the compensatory mechanisms, which are probably evoked by the T3 deficiency in order to maintain cellular homeostasis.
我们采用受体放射配体结合分析法，研究了20名正常人和43例伴有或不伴有低T3血症的糖尿病患者循环淋巴细胞中T3受体的变化。与正常对照组相比，所有糖尿病患者血清T3和FT3的平均值均显著降低。血清T3浓度与空腹血糖水平呈负相关。低T3血症患者的血清反T3明显升高。所有患者的血清T4、FT4、游离甲状腺素指数（FT4I）和促甲状腺激素（TSH）均正常。循环淋巴细胞T3受体的最大结合容量（MBC）与血清T3浓度呈负相关，糖尿病患者明显升高。低T3血症患者的MBC仍高于T3正常患者，而受体亲和力未发生改变。总之，T3受体结合容量的增加反映了一种代偿机制，这可能是由T3缺乏引起的，以维持细胞内环境稳定。
