Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad, 500 049, India.
Org Biomol Chem. 2011 Feb 21;9(4):1004-7. doi: 10.1039/c0ob00771d. Epub 2010 Dec 23.
A facile two-step method for the construction of fused pyrrole ring leading to 5-substituted 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-ones via C-C followed by intramolecular C-N bond forming reaction is described. In vitro pharmacological evaluation and molecular modelling studies of some of the compounds synthesized are presented.
描述了一种简便的两步法，通过 C-C 键形成反应和随后的分子内 C-N 键形成反应，构建融合的吡咯环，得到 5-取代的 2,3-二氢-1H-吡咯并[3,2,1-ij]喹啉-1-酮。介绍了一些合成化合物的体外药理学评价和分子建模研究。
