Lontra Marcelo Bentacor, Bigolin André Vicente, Costa Ricardo Gonçalves da, Grossi João Vicente, Scalco Priscila, Roll Sérgio, Cavazzola Leandro Totti
Lutheran University of Brazil, Canoas, RS, Brazil.
Rev Col Bras Cir. 2010 Oct;37(5):364-9. doi: 10.1590/s0100-69912010000500010.
To evaluate the efficacy of a lactic acid biomaterial (SurgiWrap®) as a protector of the polypropylene mesh (Marlex®) regarding the formation of intraperitoneal adhesions in rats.
Forty Wistar rats formed the following groups: Group 0 (Sham)--only laparotomy; Group I--polypropylene mesh; Group II--polypropylene mesh protected by a film of lactic acid. These animals were submitted to laparotomy and placement (or not) of the meshes at closing. After 21 days they were sacrificed for analysis of the adhesion type (0-3), percentage of affected area and strength needed to rupture.
Group 0 showed no intraperitoneal adhesions. Regarding classification, type 3 adhesions had the highest prevalence in both groups 1 and 2. As for the strength to break adhesions, Group 1 had an average of 1.58 N and Group 2, 1.23 N. The mesh was surrounded by adhesions in more than 50% of their surface area in 87% of Group 1 subjects and in 84% of Group 2 individuals. Through different statistical methods we found that there was no significant difference between groups for both variables.
The combined use of polypropylene mesh and lactic acid bioprotector showed similar results in relation to intraperitoneal adhesion formation when compared to the sole use of the same mesh.
评估一种乳酸生物材料（SurgiWrap®）作为聚丙烯网片（Marlex®）的保护剂在大鼠腹腔粘连形成方面的效果。
40只Wistar大鼠分为以下几组：0组（假手术组）——仅行剖腹术；I组——聚丙烯网片；II组——由乳酸膜保护的聚丙烯网片。这些动物接受剖腹术，并在关腹时放置（或不放置）网片。21天后将它们处死，以分析粘连类型（0 - 3级）、受影响面积百分比以及粘连破裂所需的强度。
0组未出现腹腔粘连。在分类方面，3级粘连在1组和2组中患病率最高。至于粘连破裂强度，1组平均为1.58 N，2组为1.23 N。在1组87%的受试动物和2组84%的个体中，网片表面超过50%被粘连包围。通过不同的统计方法，我们发现两组在这两个变量上均无显著差异。
与单独使用相同网片相比，聚丙烯网片和乳酸生物保护剂联合使用在腹腔粘连形成方面显示出相似的结果。
