Biondo-Simões Maria de Lourdes Pessole, Pessini Victor Cezar de Azevedo, Porto Pedro Henrique Caldeira, Robes Rogério Ribeiro
Universidade Federal do Paraná, Departamento de Cirurgia, Curitiba, PR, Brasil.
Rev Col Bras Cir. 2018 Dec 10;45(6):e2040. doi: 10.1590/0100-6991e-20182040.
to compare the formation of induced intraperitoneal adhesions in rats when using polypropylene and Sepramesh® meshes.
we used 20 male Wistar rats, randomly grouped in two groups of ten animals each. We arranged two 10x20mm meshes intraperitoneally into each animal, one being the polypropylene (PP), and the other, Sepramesh®. In Group 1, the polypropylene mesh was positioned to the right, and the Sepramesh®, to the left. In Group 2, the meshes' layout was reversed. After 14 days of the procedure, we euthanized the animals and analyzed the incorporation and percentages of adhesions macroscopically in each mesh. We submitted the collected data to statistical analysis with a significance level of 5% (p<0.05).
all meshes showed adhesions. In the Sepramesh® ones, the percentage of surface covered by adhesions ranged from 2% to 86%, with a mean of 18.6±18.6%, while in the polypropylene meshes, it varied between 6% and 86%, with an average of 57.4%±34.9% (p<0.05). The preferred adhesion sites on both meshes were the edges.
although no mesh was able to completely inhibit the development of adhesions, the Sepramesh® mesh presented less adhesions to the polypropylene mesh. The most common sites of adhesion formation were the edges of the prosthesis, which evidences the importance of the adequate fixation of the meshes.
比较使用聚丙烯网片和Sepramesh®网片时大鼠诱导性腹腔粘连的形成情况。
我们使用了20只雄性Wistar大鼠，随机分为两组，每组10只动物。我们将两片10×20mm的网片腹腔内植入每只动物体内，一片为聚丙烯（PP）网片，另一片为Sepramesh®网片。在第1组中，聚丙烯网片置于右侧，Sepramesh®网片置于左侧。在第2组中，网片的布局相反。手术14天后，我们对动物实施安乐死，并宏观分析每个网片上粘连的形成情况及百分比。我们将收集到的数据进行统计学分析，显著性水平为5%（p<0.05）。
所有网片均出现粘连。在Sepramesh®网片上，粘连覆盖的表面百分比在2%至86%之间，平均为18.6±18.6%，而在聚丙烯网片上，该百分比在6%至86%之间，平均为57.4%±34.9%（p<0.05）。两片网片上粘连的首选部位均为边缘。
尽管没有网片能够完全抑制粘连的形成，但Sepramesh®网片的粘连情况比聚丙烯网片少。粘连形成最常见的部位是假体边缘，这证明了网片妥善固定的重要性。
