Vrijland W W, Bonthuis F, Steyerberg E W, Marquet R L, Jeekel J, Bonjer H J
Department of General Surgery, Erasmus University Medical Center, P. O. Box 2040, 3000 CA Rotterdam, The Netherlands.
Surg Endosc. 2000 Oct;14(10):960-3. doi: 10.1007/s004640000180.
In many cases, incisional hernia repair requires the use of prosthetic materials. The aim of this experimental study in a rat model was to assess the role of polyglactin 910 mesh and fluoropassivated polyester mesh in preventing the formation of adhesions.
In the first experiment, the formation of peritoneal adhesions was assessed after insertion of polypropylene, polypropylene combined with polyglactin 910, or no mesh. In the second experiment, adhesion formations were compared after insertion of fluoropassivated polyester, polypropylene, and no mesh.
The first experiment showed no significant difference in adhesion formations between the polypropylene mesh and the combined mesh; however, when no mesh was used, there were significantly fewer adhesions in both experiments (p < 0.01). The second experiment showed a significantly lower degree of adhesions and a lower Adhesion Index after insertion of fluoropassivated polyester mesh than when polypropylene mesh was used (p = 0.04).
Adding polyglactin 910 mesh to polypropylene mesh to prevent the formation of adhesions is not an effective measure. Fluoropassivated polyester meshes appear to provide a better alternative to the use of polypropylene meshes for incisional hernia repair in humans in terms of the formation of adhesions.
在许多情况下，切口疝修补需要使用人工合成材料。本大鼠模型实验研究的目的是评估聚乙醇酸910网片和氟钝化聚酯网片在预防粘连形成中的作用。
在第一个实验中，评估植入聚丙烯、聚丙烯与聚乙醇酸910联合使用或不植入网片后腹膜粘连的形成情况。在第二个实验中，比较植入氟钝化聚酯、聚丙烯和不植入网片后的粘连形成情况。
第一个实验表明，聚丙烯网片和联合网片在粘连形成方面无显著差异；然而，在两个实验中，未使用网片时粘连明显较少（p < 0.01）。第二个实验表明，植入氟钝化聚酯网片后粘连程度明显低于使用聚丙烯网片时，粘连指数也更低（p = 0.04）。
在聚丙烯网片中添加聚乙醇酸910网片以预防粘连形成并非有效措施。就粘连形成而言，氟钝化聚酯网片似乎为人类切口疝修补中使用聚丙烯网片提供了更好的替代方案。
