Steffen A, Wollenberg B, Schönweiler R, Brüggemann N, Meyners T
Klinik für Hals-, Nasen- und Ohrenheilkunde, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.
HNO. 2011 Jan;59(1):115-7. doi: 10.1007/s00106-010-2232-5.
Drooling is both a clinical sign for the diminished control of saliva and oral motor function and a heavy social burden for patients. We report a case in which drooling deteriorated after radiotherapy of the head and neck region as the primary treatment for hypopharyngeal cancer, although radiotherapy of the salivary glands is known to be an effective treatment option for drooling. In this particular case, injection of botulinum toxin in the parotid and submandibular glands significantly reduced drooling. The excellent response to botulinum toxin is of great clinical interest for similar RT non-responders.
流涎既是唾液和口腔运动功能控制减弱的临床体征，也是患者沉重的社会负担。我们报告了一例下咽癌的主要治疗为头颈部放疗后流涎恶化的病例，尽管已知唾液腺放疗是治疗流涎的有效选择。在这个特殊病例中，在腮腺和颌下腺注射肉毒杆菌毒素显著减少了流涎。对于类似的放疗无反应者，肉毒杆菌毒素的良好反应具有极大的临床意义。
