Division of Endocrinology and Metabolism, Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital and School of Medicine, Pusan National University, Busan, Republic of Korea.
Sci Rep. 2022 Jan 10;12(1):387. doi: 10.1038/s41598-021-04402-5.
We evaluated the associations between metabolic parameters with visceral adipose tissue (VAT) volume in women with prediabetes or type 2 diabetes (T2DM), and we compared the VAT volume with the VAT area. We enrolled women aged > 20 years with prediabetes or T2DM, who underwent oral glucose tolerance test and whose VAT was evaluated using computed tomography (CT) at our institution between 2017 and 2019. All participants underwent unenhanced spiral CT with a 3-mm slice thickness from the level of the diaphragm to the level of the mid-thigh. The two VAT areas were defined as the free drawn area on the levels of the umbilicus and L2 vertebra. The VAT areas were also manually drawn from the level of the diaphragm to the level of the pelvic floor and were used to calculate the VAT volumes by summing all areas with a slice thickness of 3 mm after setting the attenuation values from -45 to -195 Hounsfield Unit. All metabolic characteristics, except blood pressure, were significantly correlated with the VAT volume. The VAT areas measured at the level of the L2 vertebra and umbilicus were correlated with serum triglyceride, high-density lipoprotein cholesterol, and Framingham steatosis index alone. Multivariable regression analyses revealed that the VAT volume was significantly associated with several metabolic parameters. In conclusion, in women with prediabetes and T2DM, the VAT volume acquired from CT-based calculation has more significant correlations with metabolic risk factors compared with the VAT area.
我们评估了代谢参数与患有前驱糖尿病或 2 型糖尿病（T2DM）的女性内脏脂肪组织（VAT）体积之间的相关性，并将 VAT 体积与 VAT 面积进行了比较。我们招募了年龄大于 20 岁的患有前驱糖尿病或 T2DM 的女性，她们在 2017 年至 2019 年期间在我们机构进行了口服葡萄糖耐量试验，并通过计算机断层扫描（CT）评估了她们的 VAT。所有参与者均接受了未增强的螺旋 CT 检查，层厚为 3 毫米，从膈肌水平到大腿中段水平。两个 VAT 区域定义为脐水平和 L2 椎骨水平的自由绘制区域。VAT 区域也从膈肌水平到骨盆底水平手动绘制，并通过在设置衰减值从-45 到-195 亨氏单位后，对所有厚度为 3 毫米的切片区域进行求和，计算 VAT 体积。除血压外，所有代谢特征均与 VAT 体积显著相关。L2 椎骨和脐水平测量的 VAT 面积与血清甘油三酯、高密度脂蛋白胆固醇和 Framingham 脂肪变性指数单独相关。多变量回归分析显示，VAT 体积与多个代谢参数显著相关。总之，在患有前驱糖尿病和 T2DM 的女性中，与基于 CT 的计算得出的 VAT 体积与代谢危险因素的相关性更强。
