Department of Pharmacology, Hanagal Shri Kumareshawara College of Pharmacy, BVVS Campus, Bagalkot 587101, Karnataka, India.
J Ethnopharmacol. 2011 Mar 24;134(2):334-8. doi: 10.1016/j.jep.2010.12.013. Epub 2010 Dec 21.
Traditionally Berberis aristata is employed for its supposed properties in treatment of joint pain and also used in alleviating symptoms of menopause.
The aim of the present study is to evaluate the antiosteoporotic effect of Berberis aristata in ovariectomized (OVX) rats.
Sprague-Dawley rats were divided into sham and OVX groups. The OVX rats were further divided into four groups, which received standard estrogen (0.0563 mg/kg) and 100, 300, and 500 mg/kg aqueous-methanol extract of Berberis aristata, daily for 42 days. The uterine weight, bone loss, ash content, biomechanical, biochemical and histopathological observation were carried out for antiosteoporotic activity.
The experimental animals treated with Berberis aristata aqueous-methanol extract showed dose dependent activity. The significant increase in uterine weight, femur BMD, ash content and lumbar hardness were observed. In addition, increased levels of calcium and phosphorus in serum and significant decreased in urine were observed as compared to control OVX group. The histopathological results also confirm the protective effect of extract.
The present findings strongly suggest that Berberis aristata possess the potent antiosteoporosis activity in ovariectomized rats and substantiates the ethnic use in treatment of postmenopausal osteoporosis.
传统上，Berberis aristata 因其被认为具有治疗关节疼痛的特性而被使用，也被用于缓解更年期症状。
本研究旨在评估 Berberis aristata 对去卵巢（OVX）大鼠的抗骨质疏松作用。
将 Sprague-Dawley 大鼠分为假手术和 OVX 组。OVX 大鼠进一步分为四组，每天分别给予标准雌激素（0.0563 mg/kg）和 100、300 和 500 mg/kg 的 Berberis aristata 水-甲醇提取物，共 42 天。进行子宫重量、骨丢失、灰分含量、生物力学、生化和组织病理学观察，以评估抗骨质疏松活性。
用 Berberis aristata 水-甲醇提取物处理的实验动物表现出剂量依赖性活性。观察到子宫重量、股骨 BMD、灰分含量和腰椎硬度显著增加。与对照组 OVX 组相比，血清中的钙和磷水平升高，尿液中的钙和磷水平降低。组织病理学结果也证实了提取物的保护作用。
本研究结果强烈表明，Berberis aristata 对去卵巢大鼠具有有效的抗骨质疏松作用，证实了其在治疗绝经后骨质疏松症中的民族用途。
