Aarhus University, Faculty of Agricultural Sciences, Department of Genetics and Biotechnology, Research Centre Foulum, DK-8830, Tjele, Denmark.
J Dairy Sci. 2011 Jan;94(1):479-86. doi: 10.3168/jds.2010-3381.
A total of 22 quantitative trait loci (QTL) were detected on 19 chromosomes for direct and maternal calving traits in cattle using a genome-wide association study. Calving performance is affected by the genotypes of both the calf (direct effect) and dam (maternal effect). To identify the QTL contributing these effects to calving characteristics, we performed a genome-wide association study using a mixed-model analysis in Danish and Swedish Holstein cattle. The analysis incorporated 2,062 progeny-tested bulls, and 36,387 single nucleotide polymorphism markers on 29 bovine autosomes were analyzed for association with 14 calving traits. Strong evidence for the presence of QTL that affect calving traits was observed on chromosomes 4, 6, 12, 18, 20, and 25. The QTL intervals were generally smaller than those described in earlier linkage studies. The identification of calving trait-associated single nucleotide polymorphisms and mapping of the corresponding QTL in small chromosomal regions will facilitate the search for candidate calving performance genes and polymorphisms.
利用全基因组关联研究，共在 19 条染色体上检测到了 22 个与牛直接和母本产犊性状相关的数量性状基因座（QTL）。产犊性能受犊牛（直接效应）和母本（母体效应）基因型的影响。为了确定对产犊特征有贡献的 QTL，我们在丹麦和瑞典荷斯坦牛中进行了一项全基因组关联研究，采用混合模型分析。该分析包括 2062 头经过后裔测试的公牛和 29 条牛常染色体上的 36387 个单核苷酸多态性标记，分析其与 14 个产犊性状的关联。在染色体 4、6、12、18、20 和 25 上观察到了影响产犊性状的 QTL 的存在，这提供了强有力的证据。QTL 区间通常比早期连锁研究中描述的要小。与产犊性状相关的单核苷酸多态性的鉴定和相应 QTL 在小染色体区域的定位将有助于寻找候选的产犊性能基因和多态性。
